Percutaneous aortic valve replacement
In percutaneous aortic valve replacement (PAVR), a synthetic valve is transported to the heart through a small hole made in groin. This procedure can be compared to that performed when placing a stent, or performing balloon angioplasty.
Aortic valve replacement is usually an invasive procedure, with considerable mortality and morbidity especially in more fragile patients. As of 2005, trials are being performed in which the dysfunctional aortic valve is replaced percutaneously, which removes the need for open heart surgery.
As of late 2006, this procedure is experimental, but initial results are encouraging.[1]
There are two current market leaders whose devices have earned CE Mark approval in Europe and are available to physicians for implantation in appropriate patients; the CoreValve device (a self-expanding valve prosthesis consisting of a Nickel-titanium frame with a tri-leaflet valve fashioned out of porcine pericardium mounted within) and the Sapien device by Edwards Lifesciences (a balloon-expandable tubular metal stent with a tri-leaflet valve fashioned out of bovine percardium mounted within).
References
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<references />, or <references group="..." />“Novel stent design for Percutaneous aortic valve replacement” - G.V.P Kumar & L.Mathew, IFMBE Proceedings, Springerlink,4th Kuala Lumpur International Conference on Biomedical Engineering 25-28 June 2008, Pages 446-448.
“Design for Percutaneous Aortic Valve Stent” – Gideon PraveenKumar & Dr.Lazar Mathew, International Conference on Biotechnology Proceedings, VIT University, Feb 8th 2008, Pages 139-140
“New Stent Design for Percutaneous Aortic Valve Replacement” - Gideon Praveen Kumar & Lazar Mathew International Journal of Cardiovascular Revascularization Medicine , (2009) , volume 10 , issue 2 , Pages 121 – 124
“Effects of Stent Design Parameters on the Aortic Endothelium" – Gideon Praveen Kumar & Lazar Mathew IFMBE Series, 13th International Conference on Biomedical Engineering, Singapore, 3–6 December 2008, volume 23, Pages 1539–1542
Further reading
- van Herwerden L, Serruys P (2002). "Percutaneous valve implantation: back to the future?". Eur Heart J. 23 (18): 1415–6. doi:10.1053/euhj.2002.3305. PMID 12208220.
- de Jaegere, Peter; Arie Pieter Kappetein; Marco Knook; Ben Ilmer; Dries van der Woerd; Yvon Deryck; Marjo de Ronde; Ricardo Boks; G. Sianos; Jurgen Ligthart; Jean-Claude Laborde; Ad Bogers; Patrick W. Serruys. "Percutaneous aortic valve replacement in a patient who could not undergo surgical treatment. A case report with the CoreValve aortic valve prosthesis.". EuroInterv 2006. pp. 1:475–479. http://www.europcronline.com/eurointervention/4th_issue/79/?ind=1. Retrieved 2006-10-18.
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- ↑ Grube E, Laborde J, Gerckens U, Felderhoff T, Sauren B, Buellesfeld L, Mueller R, Menichelli M, Schmidt T, Zickmann B, Iversen S, Stone G (2006). "Percutaneous implantation of the CoreValve self-expanding valve prosthesis in high-risk patients with aortic valve disease: the Siegburg first-in-man study". Circulation. 114 (15): 1616–24. doi:10.1161/CIRCULATIONAHA.106.639450. PMID 17015786.
