Pleiotropy (drugs)

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In pharmacology, pleiotropy is when a drug has actions other than those for which the agent was specifically developed.[1] It may include adverse effects which are detrimental ones,[1] but is often used to denote additional beneficial effects.[2]

For example, statins primarily are HMG-CoA reductase inhibitor to decrease cholesterol synthesis, but also have the beneficial effects of, for example, being antioxidants and stabilizing atherosclerotic plaques.[1]

See also

References

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  2. Rod Flower; Humphrey P. Rang; Maureen M. Dale; Ritter, James M. (2007). Rang & Dale's pharmacology. Edinburgh: Churchill Livingstone. ISBN 0-443-06911-5.