Rember

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For other uses of the chemical compound methylthioninium chloride, see Methylene blue.
Rember
File:Methylene blue-2d-skeletal.svg
Systematic (IUPAC) name
3,7-bis(Dimethylamino)-phenothiazin-5-ium chloride
Clinical data
Routes of
administration		 oral
Legal status
Legal status
  • investigational
Identifiers
CAS Number 61-73-4
ATC code none
PubChem CID 6099
Chemical data
Formula C16H18ClN3S
Molar mass 319.85 g/mol[[Script error: No such module "String".]]
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Methylthioninium chloride (INN, or methylene blue, proposed trade name Rember) is an investigational drug being developed by startup TauRx Therapeutics that has been shown in early clinical trials to be an inhibitor of Tau protein aggregation.[1][2] The drug is of potential interest for the treatment of patients with Alzheimer's disease. Its development appears to be related to claim 7 of US 6953794  Inhibition of Tau-Tau Association. TauRx Therapeutics has suggested that the mechanism by which methylene blue might delay or reverse neurodegeneration in Alzheimer's disease is as an inhibitor of Tau protein aggregation. While methylene blue arguably has an effect on Tau aggregation, it also has an effect on mitochondrial function which is likely to play an important role. In vitro studies suggest that methylene blue might be an effective remedy for both Alzheimer's and Parkinson's disease by enhancing key mitochondrial biochemical pathways. It can disinhibit and increase complex IV, whose inhibition correlates with Alzheimer's disease. [3]

2008 clinical trial results

The University of Aberdeen held a Phase IIB clinical trial[4][5] on 321 people with mild Alzheimer's disease in the United Kingdom and Singapore and found that taking the drug 3 times a day over a period of 50 weeks slows down the development of Alzheimer's disease by about 81%. [6]

The patients were split into four groups: one group taking a dose of 30mg, another taking a dose of 60mg, a third taking a dose of 100mg and the fourth taking a placebo. The 60mg dosage gave the best results, giving an 81% reduction in mental degression compared to those on the placebo. Only those on the placebo experienced a decline in mental function.

A larger Phase 3 trial is planned for 2009 with an idea to see whether methylene blue can prevent the formation of the disease in the first place.[7] TauRx are also looking into starting a trial of the drug on patients suffering from Parkinson's disease; as methylene blue also has effects on the synuclein fibres in the brain.[8]

If the results of the two trials correlate, the drug could be on the market by 2012.[5]

Debate began soon after the announcement over the funding of the drug under the UK's National Health Service.[9]

The initial press release from TauRx has been characterized as "very aggressively worded".[10] A lengthy article at the Alzheimer Research Forum provoked further comments.[11]

Other uses

Methylthioninium chloride is approved as an antidote to potassium cyanide poisoning and as a test for gastric secretion. For other uses, see Methylthioninium chloride#Medicine.

See also

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References

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External links

  • Wilkinson Emma (2008-07-29). "Alzheimer's drug 'halts' decline". BBC news. 
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pt:Rember
  1. ↑ "Experimental Alzheimer's drug shows early promise". Associated Press via azcentral.com. 2008-07-29. Retrieved 2008-07-31. 
  2. ↑ Marchione, Marilynn (2008-07-30). "Experimental Alzheimer's drug shows early promise". Associated Press. Retrieved 2008-07-30. 
  3. ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
  4. ↑ "Four Alzheimer's Clinical Trials Address a Variety of Treatment Targets - Amyloid, Tau, Synapse Formation" (Press release). Alzheimer's Association. 2008-07-29. http://www.alz.org/icad/_release_icad_072908_130pm_trials.asp. 
  5. ↑ 5.0 5.1 TauRx Therapeutics, University of Aberdeen (2008-07-29). "New treatment halts progress of Alzheimer's disease". University of Aberdeen. Retrieved 2008-07-31. 
  6. ↑ Rose, David (2008-07-30). "New drug Rember brings 'unprecedented' Alzheimer's treatment advance". The Times. Retrieved 2008-07-30. 
  7. ↑ Wilkinson, Emma (2008-07-29). "Alzheimer's drug 'halts' decline". BBC. Retrieved 2008-07-30. 
  8. ↑ "TauRx- Alzheimer's disease". TauRx Therapeutics Ltd. Retrieved 2008-08-01. 
  9. ↑ "Lyndsay Moss: Alzheimer's 'wonder drug' fuels funds debate". The Scotsman. 2008-07-31. 
  10. ↑ David Ewing Duncan. "Desperate for a cure". Portfolio.com. 
  11. ↑ Gabrielle Strobel (2008-08-07). "Chicago: Out of the Blue—A Tau-based Treatment for AD?". Alzheimer Research Forum. Retrieved 2009-01-15. 
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