Safinamide
From Self-sufficiency
| File:Safinamide.svg | |
| Systematic (IUPAC) name | |
|---|---|
|
N2-{4-[(3-fluorobenzyl)oxy]benzyl}-L-alaninamide | |
| Identifiers | |
| CAS Number | 133865-89-1 |
| ATC code | none |
| PubChem | CID 131682 |
| Synonyms | (2S)-2-[[4-[(3-Fluorophenyl)methoxy]phenyl]methylamino]propanamide |
| Chemical data | |
| Formula | C17H19FN2O2 |
| Molar mass | 302.34 g/mol[[Script error: No such module "String".]] |
| Script error: No such module "collapsible list". | |
Safinamide is a candidate drug against Parkinson's disease with multiple methods of action.[1] In 2007, a Phase III clinical trial was started.[2] It will be marketed by Merck-Serono.
Possible additional uses are restless legs syndrome (RLS) and epilepsy.[3] As of 2008[update], they are in Phase II.
Contents
Methods of action
Parkinson and RLS relevant mechanisms
Safinamide is a monoamine oxidase B inhibitor, reducing degradation of dopamine.
It is a glutamate release inhibitor.
It seems to inhibit dopamine reuptake.
Other mechanisms
Furthermore, safinamide blocks sodium and calcium channels.
References
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<references />, or <references group="..." />- ↑ Fariello, RG (2007). "Safinamide". Neurotherapeutics. 4 (1): 110–116. doi:10.1016/j.nurt.2006.11.011. PMID 17199024.
- ↑ Study of Safinamide in Early Parkinson's Disease as Add-on to Dopamine Agonist (MOTION)
- ↑ Chazot, PL (2007). "Drug evaluation: Safinamide for the treatment of Parkinson's disease, epilepsy and restless legs syndrome". Current opinion in investigational drugs. 8 (7): 570–579. PMID 17659477.
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