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...ells, and reduce aggregation of platelets. Aggregating platelets stimulate ADP and 5-HT to act on endothlial cells and help them induce relaxation of the ...n of platelets. In this case, the greater aggregation of platelets produce ADP, 5-HT, and TXA-2. However the 5-HT and the TXA-2 cause more contraction of

!Receptor <br/> (↑ = opens. ↓ = closes) <ref name=boron/> <br> <font size=1> On [ |rowspan=2| [[nitric oxide]] || ↑[[NO receptor]] on smooth muscle || ↑[[cyclic GMP|cGMP]] --> ↑[[protein kinase g|PKG]