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• Mefloquine
  ...prolonged disruption of neuronal calcium homeostasis may lead to neuronal cell death and injury, it is reasonable to suppose that such events may contribu
  13 KB (1,807 words) - 16:41, 27 September 2010
• Lidocaine
  ...m channel|voltage gated sodium (Na⁺) channels]] in the neuronal cell membrane that are responsible for signal propagation<ref name="novartis">{{ ...S) and [[cardiovascular]] effects – CNS effects usually occur at lower [[blood plasma]] concentrations and additional cardiovascular effects present at hi
  15 KB (2,006 words) - 16:41, 27 September 2010
• Chloroquine
  ...ing malaria fever, its severity correlated to the malaria parasite load in blood. There is evidence that it has a genetic basis and is related to chloroquin ...r energy metabolism. Digestion is carried out in a vacuole of the parasite cell.
  16 KB (2,187 words) - 16:41, 27 September 2010
• Prednisolone
  ...d in virtually all tissues with variable numbers between 3000 - 10000 per cell depending on the tissue involved. Prednisolone can activate and influence b -Inhibition of gene transcription for COX-2, cytokines, cell adhesion molecules and inducible NO synthetase
  7 KB (872 words) - 16:41, 27 September 2010
• Acetylcysteine
  ...reathing difficulty (due to [[bronchospasm]]), [[hypotension|a decrease in blood pressure]], rash, [[angioedema]], and sometimes also nausea and vomiting.<r ...ts (NAC, [[vitamin C]] plus [[vitamin E]], or both) may prevent or delay b-cell dysfunction in diabetes by providing protection against [[glucose]] toxicit
  28 KB (3,682 words) - 16:42, 27 September 2010
• Deferoxamine
  ...76. PMID: 17850672</ref> and release of inflammatory mediators by specific cell types<ref>Choi EY, Kim EC, Oh HM, Kim S, Lee HJ, Cho EY, Yoon KH, Kim EA, H ...(e.g. [[thalassemia]] and [[myelodysplastic syndrome]]) who require many [[blood transfusion]]s, which can greatly increase the amount of iron in the body.
  5 KB (714 words) - 20:14, 21 September 2010
• Carbamazepine
  ...[[CYP450]] inducer, may increase clearance of many drugs, decreasing their blood levels.<ref name="urleMedicine - Toxicity, Carbamazepine">{{cite web |url=h ...eatening. This occurs commonly enough that a doctor may recommend frequent blood tests during the first few months of use, followed by three to four tests p
  16 KB (2,164 words) - 16:42, 27 September 2010
• Levamisole
  Levamsiole is known to suppress the production of [[white blood cell]]s, resulting in [[neutropenia]] and [[agranulocytosis]]. With the increasi
  10 KB (1,350 words) - 16:42, 27 September 2010
• Praziquantel
  ...relatively small amount enters systemic circulation. Praziquantel has a [[Blood serum|serum]] [[half-life]] of 0.8 to 1.5 hours in adults with normal renal ...with cerebral [[cysticercosis]] experience CNS side effects related to the cell-death of the parasites (headache, worsening of preexisting neurological pro
  12 KB (1,580 words) - 16:42, 27 September 2010
• Clindamycin
  ...omycin, which causes the death of the bacteria by [[lysis|breakdown of the cell membrane]], and clindamycin, which is a powerful inhibitor of [[toxin]] syn ...patients — clindamycin therapy has been associated with [[anaphylaxis]], blood [[dyscrasia]]s, [[polyarthritis]], [[jaundice]], [[elevated transaminases|r
  25 KB (3,261 words) - 14:17, 11 September 2010
• Nitrofurantoin
  ...entration]] (MIC) is 32 [[Wiktionary:microgram|μg]]/mL or less. The peak blood concentration of nitrofurantoin following an oral dose of nitrofurantoin 10 .../ref> respiration, pyruvate metabolism and other macromolecules within the cell. It is not known which of the actions of nitrofurantoin is primarily respo
  12 KB (1,576 words) - 16:43, 27 September 2010
• Trimethoprim
  ...regnancy, especially the first [[trimester]], and for sufferers of certain blood disorders.<ref>{{cite web|Use extra precautions when taking the contrecepti ...blood clot) by lowering folic acid levels and associated bone marrow blood cell formation.
  8 KB (1,056 words) - 20:12, 10 September 2010
• Clofazimine
  ...abresi PA, Chandy KG. |title=Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases. |journal=Proc Natl Acad Sci U S A. |volume=10 ...=Treatment of chronic graft-versus-host disease with clofazimine. |journal=Blood. |volume=89 |issue=7 |pages=2298–302 |year=1997 |month=Apr |pmid=9116272
  12 KB (1,651 words) - 16:43, 27 September 2010
• Dapsone
  === Effects on the blood === ...apsone. Med J Aust 1977; 2: 247–51.</ref> Abnormalities in [[white blood cell]] formation, including [[aplastic anaemia]], are rare but the cause of the
  15 KB (2,087 words) - 16:43, 27 September 2010
• Rifampicin
  ...ars) of users, for a few hours after a dose. Maximal concentrations in the blood are decreased by about a third when the antibiotic is taken with food. <ref ...stribution to the [[central nervous system]] and penetration through the [[blood-brain barrier]].
  18 KB (2,471 words) - 16:43, 27 September 2010
• Isoniazid
  ...esis of [[mycolic acid]], required for the [[mycobacterium|mycobacterial]] cell wall. A range of radicals are produced by KatG activation of Isoniazid, inc ...e effectiveness of isoniazid. However, slow acetylation may lead to higher blood concentrations with chronic administration of the drug, with an increased r
  12 KB (1,566 words) - 16:43, 27 September 2010
• Amphotericin B
  ...so commonly used in [[tissue culture]] to prevent fungi from contaminating cell cultures. It is usually sold in a concentrated solution, either on its own ...esearchers found evidence that pore formation is not necessarily linked to cell death (i.e. Angewandte Chemie Int. Ed. Engl. 2004).<ref>Baginski, M., and J
  13 KB (1,785 words) - 16:44, 27 September 2010
• Flucytosine
  ...arrow function (e.g. [[cytostatic]]s) should be treated carefully. [[Blood cell count]]s should be taken very frequently. * Renal function: Increased [[Blood urea nitrogen|BUN]] and serum [[creatinine]] have been noted. [[Crystalluri
  10 KB (1,394 words) - 16:44, 27 September 2010
• Lamivudine
  ...first reported the anti-hepatitis B virus (HBV) activity of Lamivudine in cell culture which eventually led to the first oral antiviral agent for the trea ...ility of over 80%. Some research suggests that lamivudine can cross the [[blood-brain barrier]]. Lamivudine is often given in combination with [[zidovudine
  9 KB (1,248 words) - 16:44, 27 September 2010
• Saquinavir
  ...ion within the cell and release of mature viral particles from an infected cell. Saquinavir inhibits both HIV-1 and HIV-2 proteases. ...hat they can take less saquinavir, while maintaining sufficient saquinavir blood plasma levels to efficiently suppress the replication of HIV.
  5 KB (717 words) - 15:07, 6 July 2010

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