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Rifampicin inhibits DNA-dependent [[RNA polymerase]] in bacterial cells by binding its beta-subunit ...cannot stop the elongation of mRNA once binding to the template-strand of DNA has been initiated.<ref name="Hardman">Hardman, Joel G., Lee E. Limbird, an

...clo-GTP from the chain, which results in inhibition of further activity of DNA polymerase. Acyclo-GTP is fairly rapidly [[metabolism|metabolised]] within ...ent viral thymidine kinase; and mutations to viral thymidine kinase and/or DNA polymerase, altering substrate sensitivity.<ref name="Martindale34">Sweetma

...ester linkage essential for DNA chain elongation, and therefore, the viral DNA growth is terminated. {{Antivirals}}

Ribavirin is active against a number of [[DNA]] and [[RNA]] [[virus]]es. It is a member of the [[nucleoside]] antimetabol ...HIV antiviral didanosine (ddI, Videx). Other interactions with nucleoside antivirals for HIV should be considered when HIV/AIDS patients use ribavirin to treat