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| excretion = [[bile|biliary]] and [[renal]] ...id]] that is used to treat opioid addiction in higher dosages (>2 mg) and to control moderate pain in non-opioid tolerant individuals in lower dosage

| excretion = Urine, Test by specific gravity and bilirubin ...st. Methadone was introduced into the United States in 1947 by [[Eli Lilly and Company]].