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...[angiotensin II receptor antagonist]]s, which directly block [[Angiotensin receptor|angiotensin II AT₁ receptors]]. ...most important Gq stimulator of the heart during hypertrophy, compared to endothelin-1 and A1 adrenoreceptors.

...response to endothelin-1.<ref>Luo et al. Increased pulmonary vascular ETb receptor expression and responsiveness to ET-1 in cirrhotive and portal hypertensive ...esterase inhibitors, nitrous oxide and, most recently, endothelin receptor antagonists and agents capable of reversing the remodeling of pulmonary vasculature.