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• Allopurinol
  ...Nivorozhkin A, Szabó C | title = Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol | journal = ...bition of [[amidophosphoribosyl transferase]], the first and rate-limiting enzyme of purine biosynthesis. Allopurinol therefore decreases both uric acid form
  7 KB (864 words) - 16:41, 27 September 2010
• Chloroquine
  ...in Plasmodium falciparum and the antimalarial activity of crystallization inhibitors.| journal = Parasitol Research | volume = 100 | issue = 4 | pages = 671–6 ...[[phospholipase A]], antigen presentation in dendritic cells, release of [[enzyme]]s from [[lysosome]]s, release of [[reactive oxygen species]] from [[macrop
  16 KB (2,187 words) - 16:41, 27 September 2010
• Clindamycin
  ...acists |title=Targeting bacterial virulence: the role of protein synthesis inhibitors in severe infections. Insights from the Society of Infectious Diseases Phar ...]s, [[polyarthritis]], [[jaundice]], [[elevated transaminases|raised liver enzyme levels]], and/or [[hepatotoxicity]].<ref name=Rossi/>
  25 KB (3,261 words) - 14:17, 11 September 2010
• Chloramphenicol
  ...or = Neu HC, Gootz TD | chapter = Antimicrobial Chemotherapy:Antimicrobial Inhibitors of Ribosome Function | title = Baron's Medical Microbiology |editor=Baron ...noted for its cause of "Gray Baby Syndrome" because of infants lack of the enzyme glucoronyl transferase which is the main pathway conjugational excretion, w
  29 KB (3,876 words) - 16:42, 27 September 2010
• Nitrofurantoin
  Neonates (babies up to the age of one month) have immature enzyme systems in their [[erythrocyte|red blood cell]]s ([[glutathione]] instabili {{Nucleic acid inhibitors}}
  12 KB (1,576 words) - 16:43, 27 September 2010
• Co-trimoxazole
  | class1 = [[Dihydrofolate reductase]] [[enzyme inhibitor|inhibitor]] (16.7%) ...minobenzoic acid]] (PABA) and, thus, are [[competitive inhibitor]]s of the enzyme, inhibiting the production of [[dihydropteroic acid]].
  10 KB (1,346 words) - 16:43, 27 September 2010
• Trimethoprim
  ...d are thus dependent on their own ''de novo'' synthesis. Inhibition of the enzyme starves the bacteria of nucleotides necessary for [[DNA replication]]. ...p://www.med.sc.edu:96/Biopharm/PDFs/NucleicAcidInhibitors.pdf Nucleic acid inhibitors] (PDF file).
  8 KB (1,056 words) - 20:12, 10 September 2010
• Dapsone
  ...ase activity by promoting the formation of an inactive intermediate of the enzyme, thus preventing the conversion of hydrogen peroxide to hypochlorous acid, {{Nucleic acid inhibitors}}
  15 KB (2,087 words) - 16:43, 27 September 2010
• Rifampicin
  Rifampicin is an effective liver enzyme-inducer, promoting the upregulation of [[hepatic]] [[cytochrome P450]] enzy ...pamil]], [[nifedipine]], [[simvastatin]], [[midazolam]] and [[HIV protease inhibitors]]. Other possible interactions include [[antiretroviral agents]], [[everoli
  18 KB (2,471 words) - 16:43, 27 September 2010
• Abacavir
  ...nosine]] (a [[purine]]). Its target is the viral [[reverse transcriptase]] enzyme. ...nosine]] and [[zalcitabine]]. HIV strains that are resistant to [[protease inhibitors]] are not likely to be resistant to abacavir.
  8 KB (1,124 words) - 16:44, 27 September 2010
• Emtricitabine
  ...[[cytidine]]. The drug works by inhibiting [[reverse transcriptase]], the enzyme that copies HIV RNA into new viral DNA. By interfering with this process, w [[Category:Nucleoside analog reverse transcriptase inhibitors]]
  5 KB (667 words) - 16:44, 27 September 2010
• Lamivudine
  ...approval process switched to [[protease inhibitor (pharmacology)|protease inhibitors]]. According to the manufacturer's 2004 annual report, its patent will expi ...r incorporation into viral DNA. They inhibit the HIV reverse transcriptase enzyme competitively and act as a chain terminator of DNA synthesis. The lack of a
  9 KB (1,248 words) - 16:44, 27 September 2010
• Tenofovir
  ...nscriptase inhibitor]]s (nRTIs), which block [[reverse transcriptase]], an enzyme crucial to viral production in [[HIV]]-infected people. [[Category:Nucleoside analog reverse transcriptase inhibitors]]
  6 KB (871 words) - 16:45, 27 September 2010
• Efavirenz
  ...transcribes viral RNA into DNA. Unlike nucleoside RTIs, which bind at the enzyme's active site, NNRTIs act allosterically by binding to a distinct site away ...ase at 2.35-A resolution and the mechanism of resistance to non-nucleoside inhibitors | journal=Proc Natl Acad Sci USA | volume=99 | pages=14410–15 | pmid=1238
  10 KB (1,441 words) - 16:45, 27 September 2010
• Nevirapine
  ...transcribes viral RNA into DNA. Unlike nucleoside RTIs, which bind at the enzyme's active site, NNRTIs bind allosterically at a distinct site away from the ...ase at 2.35-A resolution and the mechanism of resistance to non-nucleoside inhibitors |journal=Proc Natl Acad Sci USA. |volume=99 |issue=22 |pages=14410–5 |yea
  15 KB (2,090 words) - 16:45, 27 September 2010
• Ritonavir
  ...n, but as it inhibits the same host enzyme that metabolizes other protease inhibitors. This inhibition leads to higher plasma concentrations of these latter drug ...cture inhibits CYP3A4, so a low dose can be used to enhance other protease inhibitors.
  9 KB (1,233 words) - 15:07, 6 July 2010
• Saquinavir
  ...zes saquinavir to an inactive form, but with the ritonavir inhibiting this enzyme, the saquinavir blood plasma levels increased considerably. Additionally, r Unlike other protease inhibitors, the absorption of saquinavir seems to be improved by [[omeprazole]].<ref>{
  5 KB (717 words) - 15:07, 6 July 2010
• Nelfinavir
  ...o the class of drugs known as [[protease inhibitor (pharmacology)|protease inhibitors]] (PIs) and like other PIs is generally used in combination with other anti ...being widely prescribed in combination with [[HIV]] reverse transcriptase inhibitors for the treatment of HIV infection. <ref>{{cite journal |author=Zhang KE, W
  8 KB (1,160 words) - 16:45, 27 September 2010
• Ribavirin
  Ribavirin 5' mono- di- and tri-phosphates, in addition, are all inhibitors of certain viral RNA-dependent RNA polymerases which are a feature of anti- ...peutic ribavirin concentrations. Any difference between cellular and viral enzyme handling of ribavirin-containin mRNA transcripts is a potential mechanism o
  23 KB (3,222 words) - 16:45, 27 September 2010
• Codeine
  ...dale RF, Sellers EM, Romach MK |title=Treatment of codeine dependence with inhibitors of cytochrome P450 2D6 |journal=J Clin Psychopharmacol |volume=22 |issue=3 ...o morphine occurs in the liver and is catalysed by the [[cytochrome P450]] enzyme [[CYP2D6]]. [[CYP3A4]] produces norcodeine and [[UGT2B7]] conjugates codein
  40 KB (5,581 words) - 16:45, 27 September 2010

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