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| metabolism = hepatic and renal [[glucuronidation]] * [[Edema]] associated with [[heart failure]], hepatic [[cirrhosis]], [[renal impairment]], [[nephrotic syndrome]]

| metabolism = [[Hepatic]] ([[CYP3A4]]) ...cessdate=2007-08-15 |format= |work=}}</ref> Cholestatic hepatitis, hepatic cirrhosis, rhabdomyolysis and myositis have been reported in patients receiving the d

| metabolism = [[Liver|Hepatic]] ...[[hypokalemia]], secondary hyperaldosteronism (such as occurs with hepatic cirrhosis), and [[Conn's syndrome]] (primary hyperaldosteronism). On its own, spiron

| metabolism = [[Liver|Hepatic]] - [[CYP2C19]] * Severe [[hepatic]] deficiencies ([[hepatitis]] and liver [[cirrhosis]] decrease elimination by a factor of 2)

|metabolism=[[Liver|Hepatic]] * Severe [[hepatic]] deficiencies ([[hepatitis]] and liver [[cirrhosis]] decrease elimination by a factor of 2)

*[[Obstructive liver disease]] (Xanthomatous biliary cirrhosis) *[[Variegate porphyria]] (Mixed hepatic porphyria, Mixed porphyria, South African genetic porphyria, South African

| Bronzed cirrhosis <br><small>''see'' [[hemochromatosis]] </small> || || | hepatic AGT deficiency <br><small>''see'' [[hyperoxaluria, primary]] </small> || ||

...upled in diseases, such as [[congestive heart failure]] (CHF) or hepatic [[cirrhosis]]. In such cases decreased ECV may lead to [[volume depletion]] responses a

...ion of liver disease, present in 0.25 to 4% of all patients suffering from cirrhosis. Once an absolute contraindication to [[liver transplantation]], it is no l ..."ReferenceA">Bejaminov et al. Portopulmonary hypertension in decompensated cirrhosis with refractory ascites. Gut 2003; 52:1355-1362</ref>

| metabolism = [[Liver|Hepatic]] ...h compromised renal function (e.g., [[heart failure]], [[diuretic]] use, [[cirrhosis]], [[dehydration]], and [[renal insufficiency]]).