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...eral years away ([[pethidine]] was invented in Germany in 1937) and opioid agonists amongst the semi-synthetics were analogues and derivatives of codeine such ...e rush is the physical sensation which is helped along by vasodilation and histamine release and the bang is the very rapid onset and increase in euphoria and s

...5, 1985 | volume = 36| issue = 8| pages = 737–44| title = Effect of GABA agonists on the neurotoxicity and anticonvulsant activity of benzodiazepines| author ...h Y, Saeki K. | date = May 27, 1986 | title = Diazepam-induced decrease in histamine turnover in mouse brain | journal = Eur J Pharmacol. | volume = 124 | issue

...eceptor antagonist), [[clonidine]] and other α₂-adrenoreceptor agonists, and [[mexiletine]] and other local anaesthetic analogues. ...r example, [[antihistamines]] including orphenadrine combat the release of histamine caused by many opioids, [[methylphenidate]], [[caffeine]], [[ephedrine]], [

Because administration of dextromethorphan can trigger a [[histamine]] release (an [[allergic]] reaction), its use in [[atopic]] children is ver Because dextromethorphan can trigger a [[histamine]] release ([[allergic reaction]]), [[atopic]] children, who are especially