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...ients are preferentially distributed to hydrophobic compartments such as [[lipid bilayers]] of cells while hydrophilic drugs (low partition coefficients) pr ...ion into the lipid bilayer, but not so hydrophobic, that once it is in the bilayer, it will not partition out again.<ref name="Kubinyi">{{cite journal |author

...ed around a water-filled pore through the plane of the membrane or [[lipid bilayer]].<ref name="isbn0-87893-741-2">{{cite book | author = Purves,| authorlink

...e non-specific interactions between the anesthetic and the [[Lipid bilayer|lipid membrane]].<ref name=Heimburg2007>{{Cite journal|last=Heimburg|first=T|coau