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• Doog food
  ...ing of the digestive system and be toxic to the other organs including the liver and kidneys. * Large amounts of liver Can cause Vitamin A toxicity, which affects muscles and bones.
  4 KB (650 words) - 21:21, 3 October 2011
• Chloroquine
  | metabolism = Liver ...agent, meaning that it accumulates preferentially in the [[lysosomes]] of cells in the body. The pKa for the quinoline nitrogen of chloroquine is 8.5, me
  16 KB (2,187 words) - 16:41, 27 September 2010
• Acetylcysteine
  ...s. This may lead to severe liver damage and even death by [[fulminant]] [[liver failure]]. ...o toxic metabolites. These actions serve to protect [[hepatocyte]]s in the liver from NAPQI toxicity.
  28 KB (3,682 words) - 16:42, 27 September 2010
• Deferoxamine
  ...Iron chelator triggers inflammatory signals in human intestinal epithelial cells: involvement of p38 and extracellular signal-regulated kinase signaling pat
  5 KB (714 words) - 20:14, 21 September 2010
• Carbamazepine
  | metabolism = [[Liver|Hepatic]]—by [[CYP3A4]], to active [[epoxide]] form (carbamazepine-10,11 ...fic patient. However, after enough carbamazepine has been presented to the liver tissue, the CYP3A4 activity increases, speeding up drug clearance and short
  16 KB (2,164 words) - 16:42, 27 September 2010
• Albendazole
  ...ientia Vol. 32..702, 1976, ''Anthelminitic Activity of Albendazole Against Liver Flukes, Tapeworms, Lung and Gastrointestinal Roundworms''</ref> ...ndazole causes degenerative alterations in the [[tegument]] and intestinal cells of the worm by binding to the [[colchicine]]-sensitive site of [[tubulin]],
  10 KB (1,261 words) - 13:28, 4 September 2010
• Levamisole
  | metabolism = [[Liver|Hepatic]] ...ively inhibits]] most [[isoform]]s of [[alkaline phosphatase]] (e.g. human liver, bone, kidney, and spleen) except the intestinal and placental isoform.<ref
  10 KB (1,350 words) - 16:42, 27 September 2010
• Praziquantel
  Praziquantel is also used to treat [[liver fluke]]s such as ''[[Clonorchis sinensis]]'', <ref name="pmid17570980">{{ci ...have a half-life of 4 to 5 hours. In patients with significantly impaired liver function (Child Pugh classes B ll///d C), the serum half-life is increased
  12 KB (1,580 words) - 16:42, 27 September 2010
• Metronidazole
  ...ctase. This reduction causes the production of toxic products to anaerobic cells, and allows for selective accumulation in anaerobes. ...appens only in anaerobic cells, it has relatively little effect upon human cells or [[aerobic bacteria]].<ref>{{Cite book|first1=Barry I. |last1=Eisenstein
  19 KB (2,528 words) - 16:43, 27 September 2010
• Nitrofurantoin
  | metabolism = liver (75%) ...l concentrated in the urine: 75% of the dose is rapidly metabolised by the liver, but 25% of the dose is excreted in the urine unchanged, reliably achieving
  12 KB (1,576 words) - 16:43, 27 September 2010
• Clofazimine
  ...tients have found [[crystal]]lized clofazimine in the intestinal mucosa, [[liver]], [[spleen]], and [[lymph nodes]]. ...handy KG. |title=The voltage-gated Kv1.3 K(+) channel in effector memory T cells as new target for MS. |journal=J Clin Invest. |volume=111 |issue=11 |pages=
  12 KB (1,651 words) - 16:43, 27 September 2010
• Dapsone
  | metabolism = [[Liver|Hepatic]] (mostly [[CYP2E1]]-mediated) ..., Molin L, Lindroth M. Granulocyte-mediated release of histamine from mast cells. Effect of myeloperoxidase and its inhibition by antiinflammatory sulfone c
  15 KB (2,087 words) - 16:43, 27 September 2010
• Rifampicin
  |metabolism = [[Liver|Hepatic]] and intestinal wall Rifampicin inhibits DNA-dependent [[RNA polymerase]] in bacterial cells by binding its beta-subunit, thus preventing transcription to [[RNA]] and s
  18 KB (2,471 words) - 16:43, 27 September 2010
• Pyrazinamide
  | metabolism = [[Liver|Hepatic]] ...f the treatment of [[tuberculous meningitis]]. It is metabolised by the [[liver]] and the metabolic products are excreted by the kidneys.
  12 KB (1,557 words) - 16:44, 27 September 2010
• Griseofulvin
  | metabolism = [[Liver|Hepatic]] [[demethylation]] and [[glucuronidation]] It binds to [[keratin]] in keratin precursor cells and makes them resistant to fungal infections. It is only when hair or skin
  5 KB (678 words) - 14:58, 19 September 2010
• Emtricitabine
  | metabolism = [[Liver|Hepatic]] [[oxidation]] and [[glucuronidation]]<br>[[Cytochrome P450 oxidas ...patient's body and can indirectly increase the number of [[immune system]] cells (called [[T cell]]s or [[Helper T cell|CD4+ T-cell]]s). Both of these chang
  5 KB (667 words) - 16:44, 27 September 2010
• Ritonavir
  ...e inhibitors. More specifically, ritonavir is used to inhibit a particular liver enzyme that normally [[metabolize]]s [[protease inhibitor]]s, [[CYP3A4|cyto ...nsulin-regulated transporter, keeping glucose from entering fat and muscle cells{{Citation needed|date=September 2008}}. This can lead to [[insulin resista
  9 KB (1,233 words) - 15:07, 6 July 2010
• Ribavirin
  ...increased concentration of the enzymes which convert amidine to amide, in liver tissue. Viramidine is in [[Clinical_trial#Phase_III|phase III]] human trial ...provided by adenine kinase. This enzyme is more active in virally infected cells.
  23 KB (3,222 words) - 16:45, 27 September 2010
• Ketamine
  ...YP3A4, CYP2B6, and CYP2C9 isoforms to N-demethylation of ketamine in human liver microsomes |journal=Drug Metabolism and Disposition |volume=30 |issue=7 |pa ...ction of ketamine with mu2 opioid receptors in SH-SY5Y human neuroblastoma cells |journal=Journal of Anesthesia |volume=13 |issue=2 |pages=107–9 |year=199
  69 KB (9,697 words) - 21:01, 24 September 2010
• Ciprofloxacin
  ...also against eukaryotic topoisomerases and are toxic to cultured mammalian cells and in vivo tumor models. |first1=C |first2=M |issn=1568-0118}}</ref> Although quinolones are highly toxic to mammalian cells in culture, its mechanism of cytotoxic action is not known. Quinolone induc
  88 KB (11,930 words) - 16:46, 27 September 2010

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