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...eral years away ([[pethidine]] was invented in Germany in 1937) and opioid agonists amongst the semi-synthetics were analogues and derivatives of codeine such ...bind to the [[sigma receptor|σ-receptor]], it has been shown that σ-agonists, such as (+)-[[pentazocine]], antagonize morphine analgesia, and σ-antagon

...c receptor|α3β4]] and the [[Alpha-4 beta-2 nicotinic receptor|α4β2]] [[nicotinic acetylcholine receptor#Subunits|subtypes]]. It was developed as a less toxi [[Category:Nicotinic agonists]]

...l [[nicotinic acetylcholine receptor]]s selective for the [[Alpha-4 beta-2 nicotinic receptor|α4β2]] subtype, and has been researched for use as an [[analgesi [[Category:Nicotinic agonists]]

...ed by [[Abbott Laboratories|Abbott]], which acts as an agonist at neural [[nicotinic acetylcholine receptor]]s and has been researched for use as an [[analgesic [[Category:Nicotinic agonists]]

...echanism for analgesic effects caused directly by THC or other cannabinoid agonists is not fully understood. Other effects include relaxation; [[euphoria]]; a ...>{{cite journal |author=Solinas M, Scherma M, Fattore L, ''et al.'' |title=Nicotinic alpha 7 receptors as a new target for treatment of cannabis abuse |journal=

The '''Cys-loop [[ligand-gated ion channel]] superfamily''' is composed of [[nicotinic]] [[acetylcholine]], [[GABA A receptor|GABA_A]], [[GABAA-rho rece *{{cite journal | author = Albuquerque et al | title = Mammalian Nicotinic Acetylcholine Receptors: from Structure to Function | journal = Physiol Rev

...wn as a cholinergic agent, cholinergic agonist,<ref>{{MeshName|Cholinergic+Agonists}}</ref> or a [[parasympathomimetic drug]],<ref name="urlDorlands Medical Di ** [[Nicotine]] ([[nicotinic receptors]])

...etjournals.org/content/299/1/366.abstract | title = Blockade of Rat α3β4 Nicotinic Receptor Function by Methadone, Its Metabolites, and Structural Analogs... ...nger duration of action compared to either heroin and other shorter-acting agonists, and the need for repeat doses of the antagonist naloxone, it is still used

In a similar manner, PCP and analogues also inhibit [[nicotinic acetylcholine receptor]] channels (nAChR). Some analogues have greater pote ...ion to displaying a positive antagonistic effect at the α7-subunit of the Nicotinic Acetylcholine Receptor (nAChR). It also binds to the mu-opioid receptor, wh

...Dextromethorphan and its metabolite dextrorphan block alpha3beta4 neuronal nicotinic receptors |journal=J. Pharmacol. Exp. Ther. |volume=293 |issue=3 |pages=962 [[Category:Sigma agonists]]