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...such as [[acetyl chloride]] via [[nucleophilic acyl substitution]]. Other substitution derivatives include [[acetic anhydride]]; this [[anhydride]] is produced by

...pical reactions are with nucleophiles which proceed via the [[Nucleophilic substitution|'''S_N2''']] mechanism both in acidic (weak nucleophiles: water, ...[[Grignard reaction|Grignard reagents]], can be regarded as [[nucleophilic substitution]] influenced by [[carbanion]] organometallic compounds. The final product o

...the ortho, meta, and para patterns of [[Arene substitution patterns|arene substitution]]—to argue in support of his proposed structure. Kekulé's symmetrical ri ...ne. Benzene is sufficiently [[nucleophile|nucleophilic]] that it undergoes substitution by [[acylium]] ions or alkyl [[carbocation]]s to give substituted derivativ