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...23">{{cite journal |author=Kehrenberg C, Schwarz S |title=Mutations in 16S rRNA and ribosomal protein S5 associated with high-level spectinomycin resistanc

...way to [[macrolide]]s. It does so by binding preferentially to the [[23S]] rRNA of the large bacterial [[ribosome]] subunit.<ref name=Merck>{{cite web | ur

...some]], binding to A2451 and A2452 residues in the [[23S ribosomal RNA|23S rRNA]] of the 50S ribosomal subunit, preventing peptide bond formation.<ref>http

...RNA]] bound at the [[A site]] of the rRNA complex to the [[P site]] of the rRNA complex. Without this translocation, the A site remains occupied and thus t

...30S [[ribosome|ribosomal]] subunit, and, through an interaction with 16S [[rRNA]], they prevent the docking of amino-acylated tRNA. <ref>Alekshun, M. N. & ...ines can arise through drug [[efflux]], ribosomal protection proteins, 16S rRNA mutation, and drug inactivation through the action of a monooxygenase.<ref>