Table of volume of distribution for drugs

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This is a table of volume of distribution (Vd) for various medication. For comparison, those with a Vd/kg body weight of less than 0.2 are mainly distributed in blood plasma, 0.2-0.7 mostly in the extracellular fluid and those with more than 0.7 are distributed throughout total body water.

Medication Vd / kg body weight
heparin 0.05-0.1[1]
insulin 0.05-0.1[1]
warfarin 0.1-0.2[1]
sulfamethoxazole 0.1-0.2[1]
glibenclamide 0.1-0.2[1]
atenolol 0.1-0.2[1]
NXY-059 0.1-0.2[2]
tubocurarine 0.2-0.4[1]
theophylline 0.4-0.7[1]
ethanol 0.7-0.9[1]
neostigmine 0.7-0.9[1]
phenytoin 0.7-0.9[1]
methotrexate 1-2[1]
indometacin 1-2[1]
paracetamol 1-2[1]
diazepam 1-2[1]
lidocaine 1-2[1]
glyceryl nitrate 2-5[1]
morphine 2-5[1]
propranolol 2-5[1]
digoxin 2-5[1]
chlorpromazine 2-5[1]
nortriptyline 2-5[1]
chloroquine 200[2]

References & footnotes

  1. 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 1.14 1.15 1.16 1.17 1.18 1.19 1.20 1.21 Rang, H. P. (2003). Pharmacology. Edinburgh: Churchill Livingstone. ISBN 0-443-07145-4.  Page 103
  2. 2.0 2.1 Estimated with a body weight of 70 kg.