Telaprevir

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Telaprevir
File:Telaprevir.png
Systematic (IUPAC) name
(1S,3aR,6aS)-2-[(2S)-2-[[(2S)-2-Cyclohexyl-2-(pyrazine-2-carbonylamino)acetyl]amino]-3,3-dimethylbutanoyl]-N-[(3S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-1-carboxamide
Identifiers
CAS Number 402957-28-2
ATC code none
PubChem CID 3010818
Chemical data
Formula C36H53N7O6
Molar mass 679.85 g/mol[[Script error: No such module "String".]]
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Telaprevir, also known as VX-950, co-developed by Vertex and Johnson & Johnson, is an experimental treatment for hepatitis C. It is a member of a class of antiviral drugs known as protease inhibitors[1]；specifically, telaprevir inhibits the hepatitis C virus NS3.4A serine protease.[2]

In a randomized controlled trial of patients in whom standard treatment with peginterferon alfa-2a and ribavirin had failed, repeat treatment with the addition of telaprevir was more likely to have a sustained response than repeat treatment with peginterferon alfa-2a and ribavirin alone.[3]

Telaprevir is the first hepatitis C drug currently in development that has demonstrated activity in patients who have failed prior therapy.[4]

References

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RNA virus antivirals (primarily J05, also S01AD and D06BB)
Hepatitis C
protease inhibitor (Boceprevir†, Telaprevir†)
Picornavirus
Anti-influenza agents
Multiple/general
Multiple/unknown
  1. ↑ Revill, P., Serradell, N., Bolos, J., Rosa, E. (2007). "Telaprevir". Drugs of the Future. 32 (9): 788. doi:10.1358/dof.2007.032.09.1138229. 
  2. ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
  3. ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
  4. ↑ Irena Melnikova (2008). "Hepatitis C therapies". Nature Reviews Drug Discovery. 7: 799–800. doi:10.1038/nrd2661. 
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