Tilorone
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| File:Tilorone.png | |
| Systematic (IUPAC) name | |
|---|---|
|
2,7-Bis(2-diethylaminoethoxy)fluoren-9-one | |
| Clinical data | |
| Routes of administration | Oral |
| Identifiers | |
| CAS Number | 27591-97-5 |
| ATC code | none |
| PubChem | CID 5475 |
| Chemical data | |
| Formula | C25H34N2O3 |
| Molar mass | 410.55 g/mol[[Script error: No such module "String".]] |
Tilorone (trade name Amixin IC) is the first recognized synthetic, small molecular weight compound that is an orally active interferon inducer.[1] It is used as an antiviral drug.
Contents
History
Tilorone was developed in the 1970s by the Physical and Chemical Institute of the National Academy of Sciences of Ukraine. It has been widely used in Ukraine since March 2005. It is produced by InterChem, based in Odessa.
Pharmacology
Tilorone actively represses the reproduction of 13 viral families: Poxviridae, Herpesviridae, Parvoviridae, Hepadnaviridae, Birnaviridae, Reoviridae, Coronaviridae, Paramyxovirus, Orthomyxoviridae, Bunyaviridae, Retroviridae and Picornaviridae.[citation needed] The mechanism of action is two-fold:
- It activates the production of interferon.
- It has a direct antiviral action.[citation needed]
Tilorone is safe for use in adults and children from the age of 7 years.[citation needed] According to the results of clinical tests, conducted in Kiev, the efficacy of prophylactic action of tilorone was 93.7%.
Uses
Tilorone is used for different viral diseases: influenza, hepatitis, herpes, diarrhea and others. In addition, it is used in the treatment of multiple sclerosis, urinary tract infections and other viral and autoimmune diseases.
References
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- ↑ Stringfellow D, Glasgow L (1972). "Tilorone hydrochloride: an oral interferon-inducing agent". Antimicrob Agents Chemother. 2 (2): 73–8. PMC 444270 Freely accessible. PMID 4670490.
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