Veliparib
From Self-sufficiency
This article is an orphan, as few or no other articles link to it. Please introduce links to this page from related articles; suggestions may be available. (February 2010) |
| File:Veliparib skeletal.svg | |
| Systematic (IUPAC) name | |
|---|---|
|
2-((R)-2-Methylpyrrolidin-2-yl)-1H-benzimidazole-4-carboxamide | |
| Identifiers | |
| ATC code | none |
| PubChem | CID 11960529 |
| Chemical data | |
| Formula | C13H16N4O |
| Molar mass | 244.29 g/mol[[Script error: No such module "String".]] |
| Script error: No such module "collapsible list". | |
Veliparib (ABT-888)[1] is a PARP inhibitor potential anti-cancer agent.
It inhibits both PARP1 and PARP2.[2] [3]
Clinical trials
Numerous phase I clinical trials are in progress.[4]
A phase I/II clinical trial for use with/out doxorubicin (for Metastatic or Unresectable Solid Tumors or Non-Hodgkin Lymphoma) started in 2008 and is due to complete in 2010.[5]
A phase II clinical trial for metastatic melanoma has started recruiting.[6]
A phase II clinical trial for metastatic breast cancer has started recruiting.[7]
It will be included in the forthcoming I-SPY2 breast cancer trial.[8]
References
Cite error: Invalid <references> tag;
parameter "group" is allowed only.
<references />, or <references group="..." />
| 40px | This antineoplastic or immunomodulatory drug article is a stub. You can help ssf by expanding it. |
- ↑ "ABT-888, an Orally Active Poly(ADP-Ribose) Polymerase Inhibitor that Potentiates DNA-Damaging Agents in Preclinical Tumor Models" May 2007
- ↑ http://www.cancer.gov/drugdictionary/?CdrID=496464
- ↑ "ABT-888, an Orally Active Poly(ADP-Ribose) Polymerase Inhibitor that Potentiates DNA-Damaging Agents in Preclinical Tumor Models", 2007
- ↑ http://clinicaltrialsfeeds.org/clinical-trials/results/term=Drug:+ABT-888
- ↑ "ABT-888 and Cyclophosphamide With Versus Without Doxorubicin in Treating Patients With Metastatic or Unresectable Solid Tumors or Non-Hodgkin Lymphoma"
- ↑ "A Study Evaluating Efficacy of ABT-888 in Combination With Temozolomide in Metastatic Melanoma"
- ↑ "ABT-888 and Temozolomide for Metastatic Breast Cancer"
- ↑ "Breast cancer study aims to speed drugs, cooperation", March 2010
Categories:
- Pages with script errors
- Pages with broken file links
- Orphaned articles from February 2010
- Articles with invalid date parameter in template
- All orphaned articles
- Infobox drug tracked parameters
- Chemical articles without CAS Registry Number
- Articles without EBI source
- Chemical pages without ChemSpiderID
- Chemical pages without DrugBank identifier
- Articles without KEGG source
- Articles without InChI source
- Articles without UNII source
- Drugs not assigned an ATC code
- Drugs with no legal status
- Articles containing unverified chemical infoboxes
- Cancer treatments
- Antineoplastic and immunomodulating drug stubs
- 2Fix
