Veratrum californicum

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Veratrum californicum
File:Veratrum californicum habitus1.jpg
Scientific classification
Kingdom: Plantae
(unranked): Angiosperms
(unranked): Monocots
Order: Liliales
Family: Melanthiaceae
Genus: Veratrum
Species: V. californicum
Binomial name
Veratrum californicum
Durand

Veratrum californicum ([California] corn lily, white or California false hellebore) is a poisonous plant native to mountain meadows in southwestern North America and the Rocky Mountains. It grows 1 to 2 meters tall, with a stem resembling a cornstalk.[1]

It is a source of jervine and cyclopamine, teratogens which can cause birth defects such as holoprosencephaly and cyclopia in animals that graze upon it. These substances inhibit the hedgehog signaling pathway.[2]

References

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fr:Veratrum californicum sv:Jättenysrot
  1. Theodore F. Niehaus, Charles L. Ripper, and Virginia Savage (1984). A Field Guide to Southwestern and Texas Wildflowers. Houghton Mifflin Company. pp. 10–11. ISBN 0-395-36640-2. 
  2. Chen, J; Taipale, J; Cooper, M. (2002). "Inhibition of Hedgehog Signaling by direct binding of Cyclopamine to Smoothened". Genes Dev. 16 (21): 2743–2748. doi:10.1101/gad.1025302. PMC 187469Freely accessible. PMID 12414725.