Veratrum californicum
From Self-sufficiency
Veratrum californicum | |
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File:Veratrum californicum habitus1.jpg | |
Scientific classification | |
Kingdom: | Plantae |
(unranked): | Angiosperms |
(unranked): | Monocots |
Order: | Liliales |
Family: | Melanthiaceae |
Genus: | Veratrum |
Species: | V. californicum |
Binomial name | |
Veratrum californicum Durand |
Veratrum californicum ([California] corn lily, white or California false hellebore) is a poisonous plant native to mountain meadows in southwestern North America and the Rocky Mountains. It grows 1 to 2 meters tall, with a stem resembling a cornstalk.[1]
It is a source of jervine and cyclopamine, teratogens which can cause birth defects such as holoprosencephaly and cyclopia in animals that graze upon it. These substances inhibit the hedgehog signaling pathway.[2]
References
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- ↑ Theodore F. Niehaus, Charles L. Ripper, and Virginia Savage (1984). A Field Guide to Southwestern and Texas Wildflowers. Houghton Mifflin Company. pp. 10–11. ISBN 0-395-36640-2.
- ↑ Chen, J; Taipale, J; Cooper, M. (2002). "Inhibition of Hedgehog Signaling by direct binding of Cyclopamine to Smoothened". Genes Dev. 16 (21): 2743–2748. doi:10.1101/gad.1025302. PMC 187469 Freely accessible. PMID 12414725.