View source for Chloroethylnorapomorphine

{{Orphan|date=February 2009}}
{{chembox
|ImageFile=Chloroethylnorapomorphine.png
|ImageSize=200px
|IUPACName=6-(2-Chloro-ethyl)-5,6,6a,7-tetrahydro-4''H''-dibenzo[de,g]quinoline-10,11-diol
|OtherNames=(-)-''N''-(2-Chloroethyl)-norapomorphine 
|Section1={{Chembox Identifiers
|  CASNo=75946-94-0
|  PubChem=156376
|  SMILES=C1CN([C@@H]2CC3=C(C4=C2C1=CC=C4)C(=C(C=C3)O)O)CCCl
  }}
|Section2={{Chembox Properties
|  Formula=C<sub>18</sub>H<sub>18</sub>ClNO<sub>2</sub>
|  MolarMass=315.79 g/mol
|  Appearance=
|  Density=
|  MeltingPt=
|  BoilingPt=
|  Solubility=
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|Section3={{Chembox Hazards
|  MainHazards=
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'''Chloroethylnorapomorphine''' is a chemical once thought to be an irreversible dopamine D2 receptor antagonist;<ref>Cohen SA, Neumeyer JL. Aporphines. 50. Kinetics of solvolysis of N-(2-chloroethyl)norapomorphine, an irreversible dopamine receptor antagonist. ''Journal of Medicinal Chemistry''. 1983 Oct;26(10):1348-53. PMID 6620296</ref><ref>Guan JH, Neumeyer JL, Filer CN, Ahern DG, Lilly L, Watanabe M, Grigoriadis D, Seeman P. Aporphines. 58. N-(2-chloroethyl) [8,9-2H]norapomorphine, an irreversible ligand for dopamine receptors: synthesis and application. ''Journal of Medicinal Chemistry''. 1984 Jun;27(6):806-10. PMID 6737423</ref> however, it was later proved to be reversible.<ref>{{cite journal | journal = European Journal of Pharmacology |year = 1982 | volume = 77 |issue = 1 | pages=85 | doi = 10.1016/0014-2999(82)90542-8 | title = Dopamine autoreceptors differ pharmacologically from postsynaptic dopamine receptors: Effects of (−)-N-(2-chloroethyl)-norapomorphine | author = Lehmann, J | pmid = 7060630 | last2 = Langer | first2 = SZ}}</ref>

==References==
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[[Category:Opioids]]
[[Category:Phenols]]
[[Category:Organochlorides]]
[[Category:Dibenzoquinolines]]


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[[Category:2Fix]]