View source for Hepatosplenomegaly

{{DiseaseDisorder infobox |
  Name           = Hepatosplenomegaly |
  ICD10          = {{ICD10|R|16|2|r|10}} |
  ICD9           = {{ICD9|571.8}}
  Image          = |
  Caption        = |
  OMIM           = |
  MedlinePlus    = 003275 |
  eMedicineSubj  = |
  eMedicineTopic = |
  DiseasesDB     = |
}}
'''Hepatosplenomegaly''' (commonly abbreviated HSM) is the simultaneous enlargement of both the [[liver]] ([[hepatomegaly]]) and the [[spleen]] ([[splenomegaly]]).  Hepatosplenomegaly can occur as the result of acute [[viral hepatitis]] or [[infectious mononucleosis]], or it can be the sign of a serious and life threatening [[lysosomal storage disease]].

==Common causes== 
* [[Infection]]:
** Acute [[viral hepatitis]]<ref name=medcyclopaedia/><ref name=gpnotebook>[http://www.gpnotebook.co.uk/simplepage.cfm?ID=1516961800 GPNotebook: hepatosplenomegaly] Retrieved on Nov 23, 2009</ref>
** [[Infectious mononucleosis]]<ref name=gpnotebook/><ref name=medcyclopaedia/>
** [[Cytomegalovirus]]<ref name=gpnotebook/><ref name=medcyclopaedia/>
** [[Rubella]]<ref name=medcyclopaedia/>
** [[Malaria]]<ref name=medcyclopaedia/>
** [[Leishmaniasis]]<ref name=medcyclopaedia/>
* [[Haematological]] disease:
** [[Myeloproliferative disease]]<ref name=gpnotebook/><ref name=medcyclopaedia>[http://www.medcyclopaedia.com/library/topics/volume_vii/h/HEPATOSPLENOMEGALY.aspx medcyclopaedia: Hepatosplenomegaly] Retrieved on Nov 23, 2009</ref>
** [[Leukaemia]]<ref name=gpnotebook/><ref name=medcyclopaedia/>
** [[Lymphoma]]<ref name=gpnotebook/><ref name=medcyclopaedia/>
** [[Pernicious anaemia]]<ref name=gpnotebook/>
** [[Sickle cell anaemia]]<ref name=gpnotebook/>
** [[Thalassaemia]]<ref name=gpnotebook/>
** [[Myelofibrosis]]<ref name=medcyclopaedia/>

* [[Metabolic]] disease:
** [[Niemann Pick disease]]

* [[Chronic liver disease]] and [[portal hypertension]]:
** [[Chronic active hepatitis]]<ref name=gpnotebook/>

* [[Amyloidosis]]<ref name=gpnotebook/>

* [[Acromegaly]]<ref name=gpnotebook/>

* [[Systemic lupus erythematosus]]<ref name=gpnotebook/>

==Rare disorders==
* [[Multiple sulfatase deficiency]]

==References==
{{reflist}}

==External links==
* [http://www.nnpdf.org/ National Niemann Pick Disease Foundation]
* [http://www.hideandseek.org/ Hide and Seek Foundation For Lysosomal Disease Research]
* {{GPnotebook|1516961800}}
* {{Medcyclopaedia|vii/h/HEPATOSPLENOMEGALY}}
[[Category:Symptoms and signs: Digestive system and abdomen]]
[[Category:Medical signs]]
[[Category:Hepatology]]
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{{Digestive system and abdomen symptoms and signs}}

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