View source for Neuropeptide Y receptor

{{protein
| Name = [[neuropeptide Y receptor Y1]]
| caption = 
| image = 
| width = 
| HGNCid = 7956
| Symbol = NPY1R
| AltSymbols = NPYR
| EntrezGene = 4886
| OMIM = 162641
| RefSeq = NM_000909
| UniProt = P25929
| PDB = 
| ECnumber = 
| Chromosome = 4
| Arm = q
| Band = 31.3
| LocusSupplementaryData = -q32
}}
{{protein
| Name = [[neuropeptide Y receptor Y2]]
| caption = 
| image = 
| width = 
| HGNCid = 7957
| Symbol = NPY2R
| AltSymbols = 
| EntrezGene = 4887
| OMIM = 162642
| RefSeq = NM_000910
| UniProt = P49146
| PDB = 
| ECnumber = 
| Chromosome = 4
| Arm = q
| Band = 31
| LocusSupplementaryData = 
}}
{{protein
| Name = [[pancreatic polypeptide receptor 1]]
| caption = 
| image = 
| width = 
| HGNCid = 9329
| Symbol = PPYR1
| AltSymbols = NPY4R, Y4, PP1
| EntrezGene = 5540
| OMIM = 601790
| RefSeq = NM_005972
| UniProt = P50391
| PDB = 
| ECnumber = 
| Chromosome = 10
| Arm = q
| Band = 11.2
| LocusSupplementaryData = 
}}
{{protein
| Name = [[neuropeptide Y receptor Y5]]
| caption = 
| image = 
| width = 
| HGNCid = 7958
| Symbol = NPY5R
| AltSymbols = 
| EntrezGene = 4889
| OMIM = 602001
| RefSeq = NM_006174
| UniProt = Q15761
| PDB = 
| ECnumber = 
| Chromosome = 4
| Arm = q
| Band = 31
| LocusSupplementaryData = -q32
}}
'''Neuropeptide Y receptors''' are a class of [[G-protein coupled receptors]] which are activated by the closely related peptide hormones [[neuropeptide Y]],  [[peptide YY]] and [[pancreatic polypeptide]].<ref name="pmid9549761">{{cite journal | author = Michel MC, Beck-Sickinger A, Cox H, Doods HN, Herzog H, Larhammar D, Quirion R, Schwartz T, Westfall T | title = XVI. International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors | journal = Pharmacol. Rev. | volume = 50 | issue = 1 | pages = 143–50 | year = 1998 | month = March | pmid = 9549761 | doi = | url = http://pharmrev.aspetjournals.org/cgi/pmidlookup?view=long&pmid=9549761 | issn = }}</ref>  These receptors are involved in control of a diverse set of behavioral processes including [[appetite]], [[circadian rhythm]], and [[anxiety]].<ref name="pmid15337373">{{cite journal | author = Heilig M | title = The NPY system in stress, anxiety and depression | journal = Neuropeptides | volume = 38 | issue = 4 | pages = 213–24 | year = 2004 | month = August | pmid = 15337373 | doi = 10.1016/j.npep.2004.05.002 | url = | issn = }}</ref><ref name="pmid16738800">{{cite journal | author = Harro J | title = CCK and NPY as anti-anxiety treatment targets: promises, pitfalls, and strategies | journal = Amino Acids | volume = 31 | issue = 3 | pages = 215–30 | year = 2006 | month = October | pmid = 16738800 | doi = 10.1007/s00726-006-0334-x | url = | issn = }}</ref><ref name="pmid17979774">{{cite journal | author = Eaton K, Sallee FR, Sah R | title = Relevance of neuropeptide Y (NPY) in psychiatry | journal = Current Topics in Medicinal Chemistry | volume = 7 | issue = 17 | pages = 1645–59 | year = 2007 | pmid = 17979774 | doi = 10.2174/156802607782341037| url = http://www.bentham-direct.org/pages/content.php?CTMC/2007/00000007/00000017/0002R.SGM | issn = }}</ref><ref name="pmid18221213">{{cite journal | author = Xapelli S, Agasse F, Ferreira R, Silva AP, Malva JO | title = Neuropeptide Y as an endogenous antiepileptic, neuroprotective and pro-neurogenic peptide | journal = Recent Patents on CNS Drug Discovery | volume = 1 | issue = 3 | pages = 315–24 | year = 2006 | month = November | pmid = 18221213 | doi = 10.2174/157488906778773689| url = http://www.bentham-direct.org/pages/content.php?PRN/2006/00000001/00000003/0008PRN.SGM | issn = }}</ref><ref name="pmid17979780">{{cite journal | author = Vona-Davis LC, McFadden DW | title = NPY family of hormones: clinical relevance and potential use in gastrointestinal disease | journal = Current Topics in Medicinal Chemistry | volume = 7 | issue = 17 | pages = 1710–20 | year = 2007 | pmid = 17979780 | doi = 10.2174/156802607782340966| url = http://www.bentham-direct.org/pages/content.php?CTMC/2007/00000007/00000017/0008R.SGM | issn = }}</ref><ref name="pmid18725086">{{cite journal | author = Lindner D, Stichel J, Beck-Sickinger AG | title = Molecular recognition of the NPY hormone family by their receptors | journal = Nutrition (Burbank, Los Angeles County, Calif.) | volume = 24 | issue = 9 | pages = 907–17 | year = 2008 | month = September | pmid = 18725086 | doi = 10.1016/j.nut.2008.06.025 | url = | issn = }}</ref>

Activated neuropeptide receptors release the [[Gi alpha subunit|G<sub>i</sub>]] subunit from the [[heterotrimeric G protein]] complex.  The G<sub>i</sub> subunit in turn inhibits the production of the [[second messenger]] [[cyclic_adenosine_monophosphate|cAMP]] from [[adenosine triphosphate|ATP]].

==Types==
There are five known mammalian [[neuropeptide Y]] receptors designated Y<sub>1</sub> through Y<sub>5</sub>.<ref name="pmid15337367">{{cite journal | author = Larhammar D, Salaneck E | title = Molecular evolution of NPY receptor subtypes | journal = Neuropeptides | volume = 38 | issue = 4 | pages = 141–51 | year = 2004 | pmid = 15337367 | doi = 10.1016/j.npep.2004.06.002 }}</ref>  Four neuropeptide Y receptors each encoded by a different gene have been identified in humans, all of which may represent therapeutic targets for obesity and other disorders.<ref name="pmid17785427">{{cite journal | author = Kamiji MM, Inui A | title = Neuropeptide y receptor selective ligands in the treatment of obesity | journal = Endocrine Reviews | volume = 28 | issue = 6 | pages = 664–84 | year = 2007 | month = October | pmid = 17785427 | doi = 10.1210/er.2007-0003 | url = | issn = }}</ref><ref name="pmid17979781">{{cite journal | author = MacNeil DJ | title = NPY Y1 and Y5 receptor selective antagonists as anti-obesity drugs | journal = Current Topics in Medicinal Chemistry | volume = 7 | issue = 17 | pages = 1721–33 | year = 2007 | pmid = 17979781 | doi = 10.2174/156802607782341028| url = http://www.bentham-direct.org/pages/content.php?CTMC/2007/00000007/00000017/0009R.SGM | issn = }}</ref><ref name="pmid17979782">{{cite journal | author = Kamiji MM, Inui A | title = NPY Y2 and Y4 receptors selective ligands: promising anti-obesity drugs? | journal = Current Topics in Medicinal Chemistry | volume = 7 | issue = 17 | pages = 1734–42 | year = 2007 | pmid = 17979782 | doi = 10.2174/156802607782340957| url = http://www.bentham-direct.org/pages/content.php?CTMC/2007/00000007/00000017/0010R.SGM | issn = }}</ref>
* [[Neuropeptide Y receptor Y1|Y<sub>1</sub>]] - {{Gene|NPY1R}}
* [[Neuropeptide Y receptor Y2|Y<sub>2</sub>]] - {{Gene|NPY2R}}
* [[Pancreatic polypeptide receptor 1|Y<sub>4</sub>]] - {{Gene|PPYR1}}
* [[Neuropeptide Y receptor Y5|Y<sub>5</sub>]] - {{Gene|NPY5R}}

==References==
{{Reflist|2}}

==External links==
*{{cite web | url = http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1292 | title = Neuropeptide Y Receptors | accessdate = | author = | authorlink = | coauthors = | date = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | language = | archiveurl = | archivedate = | quote = }}
* {{MeshName|Neuropeptide+Y+Receptor}}

{{transmembranereceptor-stub}}
{{G protein-coupled receptors}}
{{Neuropeptide receptors}}
[[Category:G protein coupled receptors]]
[[Category:2Fix]]