Neuropeptide Y receptor

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neuropeptide Y receptor Y1
Identifiers
Symbol NPY1R
Alt. symbols NPYR
Entrez 4886
HUGO 7956
OMIM 162641
RefSeq NM_000909
UniProt P25929
Other data
Locus Chr. 4 q31.3-q32
neuropeptide Y receptor Y2
Identifiers
Symbol NPY2R
Entrez 4887
HUGO 7957
OMIM 162642
RefSeq NM_000910
UniProt P49146
Other data
Locus Chr. 4 q31
pancreatic polypeptide receptor 1
Identifiers
Symbol PPYR1
Alt. symbols NPY4R, Y4, PP1
Entrez 5540
HUGO 9329
OMIM 601790
RefSeq NM_005972
UniProt P50391
Other data
Locus Chr. 10 q11.2
neuropeptide Y receptor Y5
Identifiers
Symbol NPY5R
Entrez 4889
HUGO 7958
OMIM 602001
RefSeq NM_006174
UniProt Q15761
Other data
Locus Chr. 4 q31-q32

Neuropeptide Y receptors are a class of G-protein coupled receptors which are activated by the closely related peptide hormones neuropeptide Y, peptide YY and pancreatic polypeptide.[1] These receptors are involved in control of a diverse set of behavioral processes including appetite, circadian rhythm, and anxiety.[2][3][4][5][6][7]

Activated neuropeptide receptors release the Gi subunit from the heterotrimeric G protein complex. The Gi subunit in turn inhibits the production of the second messenger cAMP from ATP.

Types

There are five known mammalian neuropeptide Y receptors designated Y1 through Y5.[8] Four neuropeptide Y receptors each encoded by a different gene have been identified in humans, all of which may represent therapeutic targets for obesity and other disorders.[9][10][11]

References

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External links

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  4. Eaton K, Sallee FR, Sah R (2007). "Relevance of neuropeptide Y (NPY) in psychiatry". Current Topics in Medicinal Chemistry. 7 (17): 1645–59. doi:10.2174/156802607782341037. PMID 17979774. 
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  6. Vona-Davis LC, McFadden DW (2007). "NPY family of hormones: clinical relevance and potential use in gastrointestinal disease". Current Topics in Medicinal Chemistry. 7 (17): 1710–20. doi:10.2174/156802607782340966. PMID 17979780. 
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  8. Larhammar D, Salaneck E (2004). "Molecular evolution of NPY receptor subtypes". Neuropeptides. 38 (4): 141–51. doi:10.1016/j.npep.2004.06.002. PMID 15337367. 
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  10. MacNeil DJ (2007). "NPY Y1 and Y5 receptor selective antagonists as anti-obesity drugs". Current Topics in Medicinal Chemistry. 7 (17): 1721–33. doi:10.2174/156802607782341028. PMID 17979781. 
  11. Kamiji MM, Inui A (2007). "NPY Y2 and Y4 receptors selective ligands: promising anti-obesity drugs?". Current Topics in Medicinal Chemistry. 7 (17): 1734–42. doi:10.2174/156802607782340957. PMID 17979782.