View source for RVD-Hpα

{{protein
| Name = RVD-Hpα fragment of hemoglobin, alpha 1
| caption = A polypeptide fragment derived from residues 92-104 (RVDPVNFKLLSH) in the human sequence
| image = 
| width = 
| HGNCid = 4823
| Symbol = [[Hemoglobin, alpha 1|HBA1]]
| AltSymbols = 
| EntrezGene = 3039
| OMIM = 141800
| RefSeq = NM_000558
| UniProt = P69905
| PDB = 
| ECnumber = 
| Chromosome = 16
| Arm = p
| Band = 13.3
| LocusSupplementaryData = 
}}

'''RVD-Hpα''' is an [[endogenous]] [[neuropeptide]] found in human and mammalian brain, which acts as a selective [[agonist]] for the [[Cannabinoid receptor 1|CB<sub>1</sub>]] [[cannabinoid receptor]]. It is a 12-amino acid [[polypeptide]] having the amino acid sequence Arg-Val-Asp-Pro-Val-Asn-Phe-Lys-Leu-Leu-Ser-His and is an [[N-terminus|N-terminal]] extended form of [[hemopressin]], a 9-AA polypeptide derived from the [[hemoglobin, alpha 1|α<sub>1</sub>]] subunit of [[hemoglobin]] which has previously been shown to act as a CB<sub>1</sub> inverse agonist.<ref>{{Cite pmid|18077343}}</ref> The shorter 11-AA polypeptide VD-Hpα was found to be an agonist at both CB<sub>1</sub> and [[Cannabinoid receptor 2|CB<sub>2</sub>]] receptors. All three polypeptides have been isolated from various mammalian species, with RVD-Hpα being one of the more abundant neuropeptides expressed in mouse brain, and these neuropeptides represent a new avenue for cannabinoid research distinct from the previously known endogenous [[lipid]]-derived cannabinoid agonists such as [[anandamide]].<ref>{{Cite pmid|19380512}}</ref>

{| class="wikitable" style="text-align:center"
|-
! species
! RVD-Hpα sequence
|-
| human
| <code>RVDPVNFKLLSH</code>
|-
| mouse
| <code>RVDPVNFKLLSH</code>
|-
| rat
| <code>RVDPVNFKfLSH</code>
|-
| consensus
| <code>RVDPVNFKxLSH</code>
|}

== References==
{{Reflist}}


{{Neuropeptides}}
{{Cannabinoids}}

[[Category:Neuropeptides]]
[[Category:Cannabinoids]]
[[Category:2Fix]]