RVD-Hpα
| RVD-Hpα fragment of hemoglobin, alpha 1 | |
|---|---|
| A polypeptide fragment derived from residues 92-104 (RVDPVNFKLLSH) in the human sequence | |
| Identifiers | |
| Symbol | HBA1 |
| Entrez | 3039 |
| HUGO | 4823 |
| OMIM | 141800 |
| RefSeq | NM_000558 |
| UniProt | P69905 |
| Other data | |
| Locus | Chr. 16 p13.3 |
RVD-Hpα is an endogenous neuropeptide found in human and mammalian brain, which acts as a selective agonist for the CB1 cannabinoid receptor. It is a 12-amino acid polypeptide having the amino acid sequence Arg-Val-Asp-Pro-Val-Asn-Phe-Lys-Leu-Leu-Ser-His and is an N-terminal extended form of hemopressin, a 9-AA polypeptide derived from the α1 subunit of hemoglobin which has previously been shown to act as a CB1 inverse agonist.[1] The shorter 11-AA polypeptide VD-Hpα was found to be an agonist at both CB1 and CB2 receptors. All three polypeptides have been isolated from various mammalian species, with RVD-Hpα being one of the more abundant neuropeptides expressed in mouse brain, and these neuropeptides represent a new avenue for cannabinoid research distinct from the previously known endogenous lipid-derived cannabinoid agonists such as anandamide.[2]
| species | RVD-Hpα sequence |
|---|---|
| human | RVDPVNFKLLSH
|
| mouse | RVDPVNFKLLSH
|
| rat | RVDPVNFKfLSH
|
| consensus | RVDPVNFKxLSH
|
References
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- ↑ Heimann, A.; Gomes, I.; Dale, C.; Pagano, R.; Gupta, A.; De Souza, L.; Luchessi, A.; Castro, L.; Giorgi, R. (2007). "Hemopressin is an inverse agonist of CB1 cannabinoid receptors". Proceedings of the National Academy of Sciences of the United States of America. 104 (51): 20588–20593. doi:10.1073/pnas.0706980105. PMC 2154475 Freely accessible. PMID 18077343.
- ↑ Gomes, I.; Grushko, J.; Golebiewska, U.; Hoogendoorn, S.; Gupta, A.; Heimann, A.; Ferro, E.; Scarlata, S.; Fricker, L. (2009). "Novel endogenous peptide agonists of cannabinoid receptors". The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 23 (9): 3020–3029. doi:10.1096/fj.09-132142. PMC 2735371 Freely accessible. PMID 19380512.
