Difference between revisions of "2,4-Dinitrochlorobenzene"
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Latest revision as of 10:05, 20 September 2010
| 2,4-Dinitrochlorobenzene | |
|---|---|
| File:1-Chloro-2,4-dinitrobenzene.png | |
| 1-Chloro-2,4-dinitro-benzene | |
| Other names Dinitrochlorobenzene; Chlorodinitrobenzene; 2,4-Dinitrochlorobenzene; 2,4-Dinitrophenyl chloride; 4-Chloro-1,3-dinitrobenzene | |
| style="background: #F8EABA; text-align: center;" colspan="2" | Identifiers | |
| Abbreviations | CDNB; DNCB |
| CAS number | 97-00-7 |
| PubChem | 6 |
| ChemSpider | 5 |
| SMILES | Script error: No such module "collapsible list". |
| style="background: #F8EABA; text-align: center;" colspan="2" | Properties | |
| Molecular formula | C6H3ClN2O4 |
| Molar mass | 202.55 g mol−1 |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) | |
| Infobox references | |
2,4-Dinitrochlorobenzene (DNCB) is a benzene derivative. It is an electrophilic, cytotoxic compound that is used in biochemical research involving glutathione-S-transferases (GSTs).
Uses
DNCB induces a type IV hypersensitivity reaction in almost all people exposed to it, so it is used medically to assess the T cell activity in patients. This is a useful diagnostic test for immunocompromised patients. It can also be used to treat warts.[1]
DNCB is used as a substrate in GST enzyme activity assays.[2] The molecule is conjugated to a single molecule of reduced glutathione which then fluoresces at 340 nm. Affinity of CDNB for each class of GST varies and so it is not a good measure of activity for some forms (e.g. GST-T).[citation needed]
Safety
DNCB can cause contact dermatitis.[3]
References
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<references />, or <references group="..." />- ↑ "Treating warts". Harvard Medical School. Retrieved April 2, 2010.
- ↑ Habig WH, Pabst MJ, Jakoby WB (1974). "Glutathione S-transferases. The first enzymatic step in mercapturic acid formation". J Biol Chem. 249 (22): 7130–7139. PMID 4436300.
- ↑ White SI, Friedmann PS, Moss C, Simpson JM (1986). "The effect of altering area of application and dose per unit area on sensitization by DNCB". Br. J. Dermatol. 115 (6): 663–8. PMID 3801307.
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- Aromatic compounds
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