AEZS-108

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AEZS-108 (previously AN-152) consists of [D-Lys(6)]LHRH linked to doxorubicin.

It is an experimental targeted therapy for various cancers (ovarian, endometrial, breast, bladder, prostate) that express LHRH receptor. The US FDA have granted it orphan drug status.

Promising results have been reported from a phase II clinical trial for ovarian cancer.[1]

It is also in a phase II trial for endometrial cancer.

References

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  1. "Phase II study of AEZS-108 (AN-152), a targeted cytotoxic LHRH analog, in patients with LHRH receptor-positive platinum resistant ovarian cancer". 2010.