Proctosedyl
Proctosedyl is the brand name for a family of two products with identical active ingredients designed to treat a variety of proctological disorders. One is a topical ointment, the other a rectal suppository. In the United Kingdom both products are contract manufactured by Patheon Limited on behalf of the Sanofi-Aventis group[1][2]. Manufacture and distribution is provided by Sanofi Aventis subsidiaries[3] Hoechst and Hoechst Marion Roussel in other territories worldwide.[4]
Application
Both the yellowish-white, translucent, greasy ointment[1] and the smooth, off-white suppositories[2] are formulated for the relief of chronic pruritus ani (otherwise known anal itching or anusitis)[1][2][5] and the treatment of pain, irritation, discharge and itching associated with haemorrhoids (otherwise known as piles)[1][2][5]. However both products are also used to provide pain relief in the treatment of anal fissure[6][7][8], for patients undergoing haemorrhoidectomy, (pre and post-operative)[8], in the relief of post-partum (otherwise known as post-natal) haemorrhoidal conditions,[9][8] and in the treatment of non-infective proctitis.[8]
Active Ingredients
Both preparations contain:
- Cinchocaine hydrochloride at a concentration of 5mg/g[1][2] to provide anaesthesia, analgesia and to act as a spasmolytic.[8]
- Hydrocortisone at a concentration of 5mg/g.[1][2] to provide antipruritic and anti-inflammatory relief[8]
Preparations in some territories may also contain:
- Framycetin sulfate at a concentration of 10 mg/g[4] as an antibacterial agent.[10]
- Aesculin at a concentration of 10 mg/g[4] for its retardant effect on Escherichia coli (otherwise known as E. Coli).[11]
References
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