Topical

This article is about topical medications. For other uses, see Topic (disambiguation).

In medicine, a topical medication is applied to body surfaces such as the skin or mucous membranes such as the vagina, anus, throat, eyes and ears.

Many topical medications are epicutaneous, meaning that they are applied directly to the skin. Topical medications may also be inhalational, such as asthma medications, or applied to the surface of tissues other than the skin, such as eye drops applied to the conjunctiva, or ear drops placed in the ear, or medications applied to the surface of a tooth. As a route of administration, topical medications are contrasted with enteral (in the digestive tract) and parenteral administration (injected into the circulatory system).

A topical effect, in the pharmacodynamic sense, may refer to a local, rather than systemic, target for a medication. However, many topically administered drugs have systemic effects.

Some hydrophobic chemicals, such as steroid hormones, can be absorbed into the body after being applied to the skin in the form of a cream, gel or lotion. Transdermal patches have become a popular means of administering some drugs for birth control, hormone replacement therapy, and prevention of motion sickness. One example of an antibiotic that may be applied topically is chloramphenicol.

The word topical is derived from the Ancient Greek topos (plural: topoi), meaning "place" or "location".

Choice of base formulation

A medication's potency often is changed with its base. For example, some topical steroids will be classified one or two strengths higher when moving from cream to ointment. As a rule of thumb, an ointment base is more occlusive and will drive the medication into the skin more rapidly than a solution or cream base.

The manufacturer of each topical products has total control over the content of the base of a medication. Although containing the same active ingredients, one manufacturer's cream might be more acidic than the next, which could cause skin irritation or change its absorption rate. For example, a vaginal formulation of miconazole antifungal cream might irritate the skin less than an athlete foot formulation of miconazole cream. These variations can, on occasion, result in different clinical outcomes, even though the active ingredient is the same. No comparative potency labeling exists to ensure equal efficacy between generic and brand name topical steroids (percentage of oil vs water dramatically affect the potency of topical steroid). Studies have confirmed that the potency of some topical steroid products may differ according to manufacturer or brand. An example of this is the case of brand name Valisone cream and Kenalog cream in clinical studies have demonstrated significantly better vasoconstrictions than some forms of this drug produced by generic drug manufacturers. However, in a simple base like an ointment, much less variation between manufacturers is common.

In dermatology, the base of a topical medication is often as important as the medication itself. It is extremely important to receive a medication in the correct base, before applying to the skin. A pharmacist should not substitute an ointment for a cream, or vice-versa, as the potency of the medication can change. Some physicians use a thick ointment to replace the waterproof barrier of the inflamed skin in the treatment of eczema, and a cream might not accomplish the same clinical intention.

Classes of topical medications

There are many general classes, with no clear dividing line between similar formulations. As a result, what the manufacturer's marketing department chooses to list on the label of a topical medication might be completely different than what the form would normally be called. For example, Eucerin "cream" is more appropriately described as an ointment than as a cream.

Solution

Topical solutions are of low viscosity and often use water or alcohol in the base. The solution can cause drying of the skin if alcohol is used in the base. These are usually a powder dissolved in water, alcohol, and sometimes oil. Frequently, in topical steroids, alcohol can cause drying if it is used as a base ingredient. There is a significant variability between generic brands and name brands. There is a risk of irritation depending on the preservative and fragrances used in the base.

Lotion

These are similar to solutions but are thicker and tend to be more emollient in nature than solution. They are usually an oil mixed with water, and more often than not have less alcohol than solutions. Lotions Can be drying if they contain a high amount of alcohol. There is a significant variability in the ingredients of base of generic lotions when compared to brand name lotions.

Shake lotion

A mixture that separates into two or three parts with time. Frequently an oil mixed with a water-based solution. Needs to be shaken into suspension before use.

Cream

Cream is thicker than lotion, and maintains its shape when removed from its container. It tends to be moderate in moisturizing tendency. For topical steroid products, oil-in-water emulsions are common. Creams have a significant risk for causing immunological sensitization due to preservatives. It has a high rate of acceptance by patients. There is a great variation in ingredients, composition, pH, and tolerance among generic brands.

Ointment

An ointment is a homogeneous, viscous, semi-solid preparation, most commonly a greasy, thick oil with a high viscosity, that is intended for external application to the skin or mucous membranes. They are used as emollients or for the application of active ingredients to the skin for protective, therapeutic, or prophylactic purposes and where a degree of occlusion is desired.

Ointments are used topically on a variety of body surfaces. These include the skin and the mucous membranes of the eye (an eye ointment), vagina, anus, and nose. An ointment may or may not be medicated.

Ointments are usually very moisturizing, and good for dry skin. They have a low risk of sensitization due to having few ingredients beyond the base oil or fat, and low irritation risk. There is typically little variability between brands of generics and namebrand drugs. They are often disliked by patients due to greasiness.

The vehicle of an ointment is known as the ointment base. The choice of a base depends upon the clinical indication for the ointment. The different types of ointment bases are:

• Hydrocarbon bases, e.g. hard paraffin, soft paraffin
• Absorption bases, e.g. wool fat, beeswax
• Water soluble bases, e.g. macrogols 200, 300, 400
• Emulsifying bases, e.g. emulsifying wax, cetrimide
• Vegetable oils, e.g. olive oil, arachis oil, coconut oil

The medicaments are dispersed in the base, and later they get divided after the drug penetration into the living cells of skin.

Ointments are formulated using hydrophobic, hydrophilic, or water-emulsifying bases to provide preparations that are immiscible, miscible, or emulsifiable with skin secretions. They can also be derived from hydrocarbon (fatty), absorption, water-removable, or water-soluble bases.

Evaluation of ointments

1. Drug content
2. Release of medicament from base
3. Medicament penetration
4. Consistency of the preparation
5. Absorption of medicament into blood stream
6. Irritant effect

Properties which affect choice of an ointment base are:

1. Stability
2. Penetrability
3. Solvent property
4. Irritant effects
5. Ease of application and removal

Methods of preparation of ointments

Trituration: In this finely subdivided insoluble medicaments are evenly distributed by grinding with a small amount of the base followed by dilution with gradually increasing amounts of the base.

Fusion: In this method the ingredients are melted together in descending order of their melting points and stirred to ensure homogeneity.

Gel

Thicker than a solution. Often a semisolid emulsion in an alcohol base. Some will melt at body temperature. Tends to be cellulose cut with alcohol or acetone. Tends to be drying. Tends to have greatly variable ingredients between generic brands and trade names. Significant risk of inducing hypersensitivity due to fragrances and preservatives. Useful for the scalp and body folds. Avoid fissures and erosions due to drying and stinging effect of alcohol base. High rate of acceptance due to its cosmetic elegance.

Foam

Can be seen with topical steroid marketed for the scalp.

Transdermal patch

Can be a very precise time release method of delivering a drug. Cutting a patch in half might affect the dose delivered. The release of the active component from a transdermal delivery systems (patch) may be controlled by diffusion through the adhesive which covers the whole patch, by diffusion through a membrane which may only have adhesive on the patch rim or drug release may be controlled by release from a polymer matrix. Cutting a patch might cause rapid dehydration of the base of the medicine, and affect the rate of diffusion.

Powder

Either the pure drug by itself (talcum powder), or mixed in a carrier such as corn starch or corn cob powder (Zeosorb AF - miconazole powder). Can be used as an inhaled topical (cocaine powder used in nasal surgery).

Solid

Medication placed in a solid form. Such as deodorant, antiperspirants, astringents, and hemostatic agents. Some solids melts when they reach body temperature (e.g. rectal suppositories).

Sponge

Certain contraceptive methods relies on the sponge as a carrier of a liquid medicine. Lemon juice embedded in a sponge has been used as a primitive contraception in some cultures.

Tape

Cordran tape is an example of a topical steroid applied under occlusion by tape. This greatly increase the potency and absorption of the topical steroid and is used to treat inflammatory skin diseases.

Vapor

Some medications are applied as an ointment or gel, and reach the mucous membrane via vaporization. Examples are nasal topical decongestants and smelling salt.

See also

• Cream (pharmaceutical)
• Finger tip unit
• Lotion
• Liniment
• Gel
• Unguent
• American Topical Association
• List of topical drugs
• Lidocaine
• Topical anesthetic
• Topical antibiotic
• Topical antifungal drugs
• Topical bacitracin
• Topical chemotherapy
• Topical corticosteroids
• Topical cream formulation
• Topical decongestant
• Topical drug delivery system
• Topical florides
• Topical gel formulation
• Topical glucocorticoids
• Topical hydrocortisone
• Topical prednisolone
• Topical steroid
• Topical solution

Topical medication forms

• Cream - Emulsion of oil and water in approximately equal proportions. Penetrates stratum corneum outer layer of skin well.
• Ointment - Combines oil (80%) and water (20%). Effective barrier against moisture loss.
• Gel - Liquefies upon contact with the skin.
• Paste - Combines three agents - oil, water, and powder; an ointment in which a powder is suspended.
• Powder

References

• Goodman & Gilman's The Pharmacological Basis of Therapeutics
• Dr. David Edwards - Dentistry Microbiology Lecture series

External links

• History of ointments

de:Lokaltherapie zh:外用