Therapeutic Targets Database
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Therapeutic Targets Database (TTD, Link) is a database provided by Bioinformatics and Drug Design Group in National University of Singapore, which provides information about the known and explored therapeutic protein and nucleic acid targets [1][2][3], the targeted disease, pathway information and the corresponding drugs directed at each of these targets. Also included in this database are links to relevant databases containing information about target function, sequence, 3D structure, ligand binding properties, enzyme nomenclature and drug structure, therapeutic class, clinical development status [4].
Content
This database currently contains more than 1500 targets, including >300 successful, >250 clinical trial and >1000 research targets, and more than 4000 drugs, including >1500 approved, >1000 clinical trial and >1500 experimental drugs. Targets and drugs in this database cover 61 protein biochemical class and 140 drug therapeutic classes respectively [4].
Related Databases
References
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- ↑ Hopkins AL, Groom CR (2002). "The druggable genome". Nat Rev Drug Discov. 1 (9): 727–30. doi:10.1038/nrd892. PMID 12209152.
- ↑ Overington JP, Al-Lazikani B, Hopkins AL (2006). "How many drug targets are there?". Nat Rev Drug Discov. 5 (12): 993–6. doi:10.1038/nrd2199. PMID 17139284.
- ↑ Zheng CJ, Han LY, Yap CW, Ji ZL, Cao ZW, Chen YZ (2006). "Therapeutic targets: progress of their exploration and investigation of their characteristics". Pharmacol Rev. 58 (2): 259–79. doi:10.1124/pr.58.2.4. PMID 16714488.
- ↑ 4.0 4.1 Chen X, Ji ZL, Chen YZ (2002). "TTD: Therapeutic Target Database". Nucleic Acids Res. 30 (1): 412–5. doi:10.1093/nar/30.1.412. PMC 99057 Freely accessible. PMID 11752352.
- ↑ Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M (2008). "DrugBank: a knowledgebase for drugs, drug actions and drug targets". Nucleic Acids Res. 36 (1): 901–6. doi:10.1093/nar/gkm958. PMC 2238889 Freely accessible. PMID 18048412.
- ↑ Liu T, Lin Y, Wen X, Jorissen RN, Gilson MK (2006). "BindingDB: a web-accessible database of experimentally determined protein-ligand binding affinities". Nucleic Acids Res. 35 (1): 198–201. doi:10.1093/nar/gkl999. PMC 1751547 Freely accessible. PMID 17145705.
