Efungumab
From Self-sufficiency
Revision as of 20:28, 5 August 2010 by 208.116.128.56 (Talk)
| Monoclonal antibody | |
|---|---|
| Type | Single-chain variable fragment |
| Source | Template:Infobox drug/mab source |
| Target | fungal Hsp90 |
| Clinical data | |
| Routes of administration | Intravenous |
| Pharmacokinetic data | |
| Bioavailability | Not applicable (IV only) |
| Protein binding | High |
| Biological half-life | 1–2 hours |
| Identifiers | |
| ATC code | none |
| Chemical data | |
| Molar mass | Approximately 27.2 kDa |
Efungumab (trade name Mycograb) is a drug developed by NeuTec Pharma (a subsidiary of Novartis), intended to treat invasive Candida infection in combination with amphotericin B. The European Medicines Agency has twice refused to grant marketing authorization for Mycograb, citing product safety and quality issues.[1]
Chemically, efungumab is a single-chain variable fragment of a human monoclonal antibody.[2] As such, it potentially act similarly to an IgA - inhibiting by binding and blocking.
References
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- ↑ European Medicines Agency (2007). REFUSAL CHMP ASSESSMENT REPORT FOR MYCOGRAB. Procedure No. EMEA/H/C/658PDF (370 KiB). London: European Medicines Agency. Retrieved on 2007-11-20. Detailed assessment report with comprehensive overview of reasons for refusal of marketing authorization.
- ↑ World Health Organization (2006). "International Nonproprietary Names for Pharmaceutical Substances (INN). Proposed INN: List 95" (PDF). WHO Drug Information. 20 (2): 48.
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