Trenbolone

Trenbolone

File:Trenbolone.png
Systematic (IUPAC) name
17β-Hydroxyestra-4,9,11-trien-3-one
Clinical data
Pregnancy category	X
Routes of administration	Intramuscular
Legal status
Legal status	Illegal (US) Schedule IV (CA)
Pharmacokinetic data
Bioavailability	100% (intramuscular)
Metabolism	?
Biological half-life	48-72 Hours
Excretion	Urinary
Identifiers
CAS Number	10161-33-8
ATC code	none
PubChem	CID 25015
ChemSpider	23383
Chemical data
Formula	C18H22O2
Molar mass	270.37[[]]

Trenbolone is a steroid used by veterinarians on livestock to increase muscle growth and appetite. To increase its effective half-life, trenbolone is not used in an unrefined form, but is rather administered as ester derivatives such as trenbolone acetate, trenbolone enanthate or trenbolone cyclohexylmethylcarbonate. Plasma lipases then cleave the ester group in the bloodstream leaving free trenbolone.

Illicit use

Bodybuilders and athletes have been known to use the drug illicitly in order to increase body mass more effectively than by weight training alone. A normal bodybuilding dosage can range from 200 mg/week up to 1400 mg/week. Due to the relatively short metabolic half-life of trenbolone acetate, dosages are commonly split into injections at least once every two days. Trenbolone enanthate can be injected once a week.

Trenbolone acetate is often referred to as "Fina" by users, because injectible trenbolone acetate is often prepared from Finaplix H pellets, an ear-implant used by cattle ranchers to maintain the weight of cattle during shipping to slaughter.

Trenbolone compounds have a binding affinity for the androgen receptor five times as high as that of testosterone. Once metabolized, the drugs have the effect of increasing nitrogen uptake by muscles, leading to an increase in the rate of protein synthesis. It also has the secondary effects of stimulating appetite, reducing the amount of fat being deposited in the body, and decreasing the rate of catabolism. Trenbolone has proven popular with anabolic steroid users as it is not metabolized by aromatase or 5α-reductase into estrogenic compounds such as estradiol, or into DHT. This means that it also does not cause any water retention normally associated with highly androgenic steroidal compounds like methandrostenolone.

Short-term side effects include insomnia, high blood pressure, night sweats, increased aggression and libido . However, since women will suffer virilization effects even at small doses, this drug should not be taken by a female. Kidney toxicity has been suggested, but has not yet been proven, and scientific evidence supporting the idea is absent from the bodybuilding community that perpetuates this idea. The origin of this myth most likely has to do with the rust colored oxidized metabolites of trenbolone which are excreted in urine and often mistaken for blood. Trenbolone and 17epi-trenbolone are both excreted in urine as conjugates that can be hydrolyzed with beta-glucuronidase. This implies that trenbolone leaves the body as beta-glucuronides or sulfates.

External links

• Intervet
• Many faces of Tren ENDING THE CONFUSION

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