Dexrazoxane
| File:Dexrazoxane.svg | |
| Systematic (IUPAC) name | |
|---|---|
|
4-[(2S)-2-(3,5-dioxopiperazin-1-yl)propyl]piperazine-2,6-dione | |
| Identifiers | |
| CAS Number | 24584-09-6 |
| ATC code | V03AF02 (WHO) |
| PubChem | CID 71384 |
| DrugBank | APRD00090 |
| ChemSpider | 64479 |
| Chemical data | |
| Formula | C11H16N4O4 |
| Molar mass | 268.269 g/mol[[Script error: No such module "String".]] |
| Script error: No such module "collapsible list". | |
| (verify) | |
Dexrazoxane hydrochloride (Zinecard by Pfizer in USA and Canada; Cardioxane by Novartis for EU and other countries) is a cardioprotective agent.
Uses
It is used to protect the heart against the cardiotoxic side effects of anthracyclines,[1] such as doxorubicin.[2]
FDA has also approved a dexrazoxane hydrochloride drug, brand name Totect or Savene (developed by TopoTarget), for use as a treatment of extravasation resulting from IV anthracycline chemotherapy.[3][4] Extravasation is an adverse event in which chemotherapies containing anthracylines leak out of the blood vessel and necrotize the surrounding tissue.
Mechanism
As a derivative of EDTA, dexrazoxane chelates iron, but the precise mechanism by which it protects the heart is not known.
References
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- ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
- ↑ Totect label on FDA's website
- ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
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