Oxycodone/naloxone

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Oxycodone/naloxone
File:Oxycodone.svg
File:Naloxone.svg
Combination of
Oxycodone Opioid analgesic
Naloxone Opioid receptor antagonist
Clinical data
Routes of
administration		 Oral
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The combination oxycodone/naloxone is available as prolonged-release tablets under the trade name Targin (produced by Mundipharma). It "significantly improv[ed] opioid-induced constipation" in a 2008 study.[1] It was released in 2006 in Germany and will be available in some other European countries beginning in 2009.[2]

References

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Softeners, emollients
Contact laxatives
Bulk producers
Osmotically acting laxatives
Enemas
Peripheral opioid antagonists
Alvimopan · Methylnaltrexone · Oxycodone/naloxone
Prostaglandins


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  1. ↑ Simpson K; et al. (2008 Dec). "Fixed-ratio combination oxycodone/naloxone compared with oxycodone alone for the relief of opioid-induced constipation in moderate-to-severe noncancer pain". Curr Med Res Opin. 24 (12): 3503–3512. doi:10.1185/03007990802584454. PMID 19032132. Retrieved 2009-04-09.  Check date values in: |date= (help)
  2. ↑ Mundipharma (2009-01-26). "Targin (oral oxycodone/naloxone prolonged-release tablet) now launching across Europe to control severe chronic pain with significantly reduced risk of opioid-induced constipation". Retrieved 2009-04-09. 
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