Penitrem A
From Self-sufficiency
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| Penitrem A | |
|---|---|
| File:Penitrem A.png | |
| Other names Tremortin | |
| style="background: #F8EABA; text-align: center;" colspan="2" | Identifiers | |
| CAS number | 12627-35-9 |
| PubChem | 337313 |
| SMILES | Script error: No such module "collapsible list". |
| style="background: #F8EABA; text-align: center;" colspan="2" | Properties | |
| Molecular formula | C37H44ClNO6 |
| Molar mass | 634.20136 |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) | |
| Infobox references | |
Penitrem A (tremortin) is a fungal neurotoxin found on ryegrass. It is produced by certain species of Aspergillus, Claviceps, and Penicillium. It inhibits potassium channels in smooth muscles.[citation needed] The maxi-channels targeted have their highest density in the cerebellar Purkinje cells.
It causes a stagger in horses and cattle.
Effective dose
The ED50 for penitrem A is 10 nM.[citation needed] The ED50 is the effective dose for 50% of the population. Many toxic chemicals do not show ED-50s and act by irreversible covalent adduction.
Stages of toxicity
See also
References
- Walter SL (2002). "Acute penitrem A and roquefortine poisoning in a dog". Can. Vet. J. 43 (5): 372–4. PMC 339273 Freely accessible. PMID 12001505.
