Epoxygenase
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Revision as of 13:39, 19 September 2009 by Tassedethe (Talk) (Removed category Inflammation; Quick-adding category Inflammations (using HotCat))
Epoxygenase is an enzyme that produces hydroxyeicosatetraenoic acids (HETEs) and epoxyeicosatrienoic acids (EETs) from arachidonic acid, causing effects such as cell proliferation and decrease in cyclooxygenase activity. [1]
Contents
[hide]Effects
HETEs
Hydroxyeicosatetraenoic acids cause:
- In mononuclear leukocytes: Cell proliferation, calcium release from intracellular stores and decreased TNF production. [1]
- Suggested to destruct beta cells, contributing to type 1 diabetes [1]
- In endothelial cells: Decreased release of fibrinolytic factors and decrease binding of antithrombin[1]
- Cell proliferation and migration of vascular smooth muscle cells, suggesting contribution to atherosclerosis.[1]
- Vasoconstriction, increased myogenic mechanism sensitivity in renal and cerebral arteries.[1]
EETs
Further information: Epoxyeicosatrienoic acid
Generally, EETs cause:
- Calcium release from intracellular stores[1]
- Increased sodium-hydrogen antiporter activity[1]
- Increased cell proliferation[1]
- Decreased cyclooxygenase activity[1]
References
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