Ritonavir

Ritonavir

File:Ritonavir.png
Systematic (IUPAC) name
1,3-thiazol-5-ylmethyl N-[(2S,3S,5S)-3-hydroxy-5-[(2S)-3-methyl-2-{[methyl({[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl})carbamoyl]amino}butanamido]-1,6-diphenylhexan-2-yl]carbamate
Clinical data
Pregnancy category	B (U.S.)
Routes of administration	oral
Legal status
Legal status	℞-only (U.S.)
Pharmacokinetic data
Protein binding	98-99%
Biological half-life	3-5 hours
Excretion	mostly fecal
Identifiers
CAS Number	155213-67-5
ATC code	J05AE03 (WHO)
PubChem	CID 392622
DrugBank	APRD00312
Chemical data
Formula	C37H48N6O5S2
Molar mass	720.946 g/mol[[]]

Ritonavir, with trade name Norvir (Abbott Laboratories), is an antiretroviral drug from the protease inhibitor class used to treat HIV infection and AIDS.

Ritonavir is frequently prescribed with HAART, not for its antiviral action, but as it inhibits the same host enzyme that metabolizes other protease inhibitors. This inhibition leads to higher plasma concentrations of these latter drugs, allowing the clinician to lower their dose and frequency and improving their clinical efficacy.

History

Ritonavir is manufactured as Norvir by Abbott Laboratories. Research that led to the drug's development was financed by a $3,500,000 federal grant through the National Institutes of Health (NIH) and over $200,000,000 by Abbott Labs. Most of the $200,000,000 figure cited by Abbott paid for clinical trials-despite NIH offering to pay for them-because Abbott was concerned about "public interest" responses to the high prices they projected Norvir would command. The Food and Drug Administration (FDA) approved ritonavir on March 1, 1996, making it the seventh approved antiretroviral drug in the United States. In 2003, Abbott raised the price of a Norvir course from USD $1.71 per day to $8.57 per day, leading to claims of price gouging by patients' groups and some members of Congress. Consumer group Essential Inventions petitioned the NIH to override the Norvir patent, but the NIH announced on August 4, 2004 that it would not invoke its legal right to allow generic production of Norvir, citing potential adverse effects on the pharmaceutical market.

Method of action

File:HIV protesase with ritonavir.png

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Ritonavir was originally developed as an inhibitor of HIV protease. It is one of the most complex inhibitors. It is now rarely used for its own antiviral activity, but remains widely used as a booster of other protease inhibitors. More specifically, ritonavir is used to inhibit a particular liver enzyme that normally metabolizes protease inhibitors, cytochrome P450-3A4 (CYP3A4). The drug's molecular structure inhibits CYP3A4, so a low dose can be used to enhance other protease inhibitors. This discovery, which has drastically reduced the adverse effects and improved the efficacy of PI's and HAART, was first communicated in an article published in the AIDS Journal in 1997 by the University of Liverpool. This effect does come with a price: it also affects the efficacy of numerous other medications, making it difficult to know how to administer them concurrently. In addition it can cause a large number of side-effects on its own.

Drug interactions

Concomitant therapy of ritonavir with a variety of medications may result in serious and sometimes fatal drug interactions . These interactions can occur with strong inhibitors, strong or moderate inducers or substrates of hepatic cytochrome P450 CYP3A4 isoform.

The list of clinically significant interactions of ritonavir includes but is not limited to following drugs:

• amiodarone - decreased metabolism, possible toxicity
• midazolam and triazolam - contraindicated
• carbamazepine - decreased metabolism, possible toxicity
• cisapride - decreased metabolism, possible prolongation of Q-T interval and life-threatening arrythmias
• disulfiram (with ritonavir oral preparation) - decreased metabolism of ritonavir
• eplerenone
• etravirine
• flecainide - decreased metabolism, possible toxicity
• MDMA
• meperidine - build-up of toxic concentrations of a metabolite possible
• nilotinib
• nisoldipine
• pimozide
• quinidine
• ranolazine
• salmeterol
• St John's wort
• statins - decreased metabolism, without dosage modification increased risk of rhabomyolisis
• thioridazine
• topotecan
• voriconazole - ritonavir increases metabolism of voriconazole

Side effects

The most common side effects of ritonavir therapy are:

• asthenia, malaise
• diarrhea
• nausea and vomiting
• abdominal pain
• dizziness
• insomnia
• sweating
• taste abonormality
• metabolic
  • hypercholesterolemia
  • hypertriglyceridemia
  • elevated transaminases
  • elevated CPK

One of ritonavir's side effects is hyperglycemia. It appears that ritonavir directly inhibits the GLUT4 insulin-regulated transporter, keeping glucose from entering fat and muscle cells. This can lead to insulin resistance and cause problems for Type Ⅱ diabetics.

Conformational polymorphism

Norvir was originally dispensed as an ordinary capsule, which did not require refrigeration. This original capsule exhibited strong conformational polymorphism. This threatened existing supplies of ritonavir as the lower energy polymorph caused the therapeutically effective polymorph to convert to the lower energy polymorph on contact. This lower energy polymorph, which was not therapeutically effective, entered production lines and effectively halted production processes. After this discovery in the late 1990s, Abbot withdrew the original capsules from the market, and recommended patients switch to Norvir suspension while researchers worked to solve the problem. The capsules have been replaced with refrigerated gelcaps, to solve the crystallization problem of the original capsules.

References

• http://www.rxabbott.com/pdf/norpi2a.pdf

Further reading

• Chemburkar, Sanjay R.; Bauer, John; Deming, Kris; Spiwek, Harry; Patel, Ketan; Morris, John; Henry, Rodger; Spanton, Stephen; Dziki, Walter (2000). "Dealing with the Impact of Ritonavir Polymorphs on the Late Stages of Bulk Drug Process Development". Organic Process Research & Development. 4: 413. doi:10.1021/op000023y. 

External links

• PubPK - Ritonavir pharmacokinetics
• Norvir (manufacturer's website)
• Ritonavir (patient information)

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