Panadol extend

PANADOL EXTEND is a novel modified release formulation of paracetamol. It is a bi-layer tablet containing paracetamol 665 mg, one layer containing immediate release (IR) paracetamol (31%) and the second layer containing sustained release (SR) paracetamol (69%). The recommended dosage is two 665 mg tablets (1.33 g) t.i.d. with a maximum daily dose of six tablets (3.99 g). These proportions result in a dissolution profile which releases paracetamol to give plasma levels adequate for analgesic relief for up to 8 hours. It is anticipated that the extended duration of action, compared with conventional dosage forms, will provide patients with a more convenient product, especially for use in conditions that require dosing for more persistent pain.