View source for FZD4

{{PBB|geneid=8322}}
'''Frizzled-4''' is a [[protein]] that in humans is encoded by the ''FZD4'' [[gene]].<ref name="pmid10544037">{{cite journal | author = Kirikoshi H, Sagara N, Koike J, Tanaka K, Sekihara H, Hirai M, Katoh M | title = Molecular cloning and characterization of human Frizzled-4 on chromosome 11q14-q21 | journal = Biochem Biophys Res Commun | volume = 264 | issue = 3 | pages = 955–61 | year = 1999 | month = Dec | pmid = 10544037 | pmc =  | doi = 10.1006/bbrc.1999.1612 }}</ref><ref name="pmid15024691">{{cite journal | author = Toomes C, Bottomley HM, Jackson RM, Towns KV, Scott S, Mackey DA, Craig JE, Jiang L, Yang Z, Trembath R, Woodruff G, Gregory-Evans CY, Gregory-Evans K, Parker MJ, Black GC, Downey LM, Zhang K, Inglehearn CF | title = Mutations in LRP5 or FZD4 underlie the common familial exudative vitreoretinopathy locus on chromosome 11q | journal = Am J Hum Genet | volume = 74 | issue = 4 | pages = 721–30 | year = 2004 | month = Mar | pmid = 15024691 | pmc = 1181948 | doi = 10.1086/383202 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FZD4 frizzled homolog 4 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8322| accessdate = }}</ref> FZD4 has also been designated as '''CD344''' ([[cluster of differentiation]] 344).

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by other experimental evidence.<ref name="entrez">{{cite web | title = Entrez Gene: FZD4 frizzled homolog 4 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8322| accessdate = }}</ref>
}}

==See also==
* [[Frizzled]]

==References==
{{reflist}}

==External links==
*{{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3062 | title = Frizzled Receptors: FZD<sub>4</sub> | accessdate = | author = | authorlink = | coauthors = | date = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | language = | archiveurl = | archivedate = | quote = }}]
*[http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=fevr  GeneReview/NIH/UW entry on Familial Exudative Vitreoretinopathy, Autosomal Dominant]

==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Li Y, Fuhrmann C, Schwinger E, ''et al.'' |title=The gene for autosomal dominant familial exudative vitreoretinopathy (Criswick-Schepens) on the long arm of chromosome 11. |journal=Am. J. Ophthalmol. |volume=113 |issue= 6 |pages= 712–3 |year= 1992 |pmid= 1598965 |doi=  }}
*{{cite journal  | author=Tanaka S, Akiyoshi T, Mori M, ''et al.'' |title=A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 17 |pages= 10164–9 |year= 1998 |pmid= 9707618 |doi=10.1073/pnas.95.17.10164  | pmc=21479  }}
*{{cite journal  | author=Sagara N, Kirikoshi H, Terasaki H, ''et al.'' |title=FZD4S, a splicing variant of frizzled-4, encodes a soluble-type positive regulator of the WNT signaling pathway. |journal=Biochem. Biophys. Res. Commun. |volume=282 |issue= 3 |pages= 750–6 |year= 2001 |pmid= 11401527 |doi= 10.1006/bbrc.2001.4634 }}
*{{cite journal  | author=Takeda S, Kadowaki S, Haga T, ''et al.'' |title=Identification of G protein-coupled receptor genes from the human genome sequence. |journal=FEBS Lett. |volume=520 |issue= 1-3 |pages= 97–101 |year= 2002 |pmid= 12044878 |doi=10.1016/S0014-5793(02)02775-8  }}
*{{cite journal  | author=Hering H, Sheng M |title=Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95. |journal=FEBS Lett. |volume=521 |issue= 1-3 |pages= 185–9 |year= 2002 |pmid= 12067714 |doi=10.1016/S0014-5793(02)02831-4  }}
*{{cite journal  | author=Robitaille J, MacDonald ML, Kaykas A, ''et al.'' |title=Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy. |journal=Nat. Genet. |volume=32 |issue= 2 |pages= 326–30 |year= 2002 |pmid= 12172548 |doi= 10.1038/ng957 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal  | author=Chen W, ten Berge D, Brown J, ''et al.'' |title=Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4. |journal=Science |volume=301 |issue= 5638 |pages= 1391–4 |year= 2003 |pmid= 12958364 |doi= 10.1126/science.1082808 }}
*{{cite journal  | author=Toomes C, Downey LM, Bottomley HM, ''et al.'' |title=Identification of a fourth locus (EVR4) for familial exudative vitreoretinopathy (FEVR). |journal=Mol. Vis. |volume=10 |issue=  |pages= 37–42 |year= 2004 |pmid= 14737064 |doi=  }}
*{{cite journal  | author=Yao R, Natsume Y, Noda T |title=MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap. |journal=Oncogene |volume=23 |issue= 36 |pages= 6023–30 |year= 2005 |pmid= 15195140 |doi= 10.1038/sj.onc.1207817 }}
*{{cite journal  | author=Toomes C, Bottomley HM, Scott S, ''et al.'' |title=Spectrum and frequency of FZD4 mutations in familial exudative vitreoretinopathy. |journal=Invest. Ophthalmol. Vis. Sci. |volume=45 |issue= 7 |pages= 2083–90 |year= 2004 |pmid= 15223780 |doi=10.1167/iovs.03-1044  }}
*{{cite journal  | author=Omoto S, Hayashi T, Kitahara K, ''et al.'' |title=Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R). |journal=Ophthalmic Genet. |volume=25 |issue= 2 |pages= 81–90 |year= 2004 |pmid= 15370539 |doi= 10.1080/13816810490514270 }}
*{{cite journal  | author=Yoshida S, Arita R, Yoshida A, ''et al.'' |title=Novel mutation in FZD4 gene in a Japanese pedigree with familial exudative vitreoretinopathy. |journal=Am. J. Ophthalmol. |volume=138 |issue= 4 |pages= 670–1 |year= 2004 |pmid= 15488808 |doi= 10.1016/j.ajo.2004.05.001 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal  | author=Qin M, Hayashi H, Oshima K, ''et al.'' |title=Complexity of the genotype-phenotype correlation in familial exudative vitreoretinopathy with mutations in the LRP5 and/or FZD4 genes. |journal=Hum. Mutat. |volume=26 |issue= 2 |pages= 104–12 |year= 2006 |pmid= 15981244 |doi= 10.1002/humu.20191 }}
*{{cite journal  | author=Nallathambi J, Shukla D, Rajendran A, ''et al.'' |title=Identification of novel FZD4 mutations in Indian patients with familial exudative vitreoretinopathy. |journal=Mol. Vis. |volume=12 |issue=  |pages= 1086–92 |year= 2006 |pmid= 17093393 |doi=  }}
*{{cite journal  | author=Planutis K, Planutiene M, Moyer MP, ''et al.'' |title=Regulation of norrin receptor frizzled-4 by Wnt2 in colon-derived cells. |journal=BMC Cell Biol. |volume=8 |issue=  |pages= 12 |year= 2007 |pmid= 17386109 |doi= 10.1186/1471-2121-8-12  | pmc=1847812 }}
}}
{{refend}}

{{transmembranereceptor-stub}}
{{NLM content}}
{{Clusters of differentiation}}
{{G protein-coupled receptors}}

[[Category:Clusters of differentiation]]
[[Category:G protein coupled receptors]]

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