FZD4

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Frizzled homolog 4 (Drosophila)
Identifiers
SymbolsFZD4; EVR1; FEVR; FZD4S; Fz-4; FzE4; GPCR; MGC34390
External IDsOMIM604579 MGI108520 HomoloGene7325 IUPHAR: FZD4 GeneCards: FZD4 Gene
RNA expression pattern
250px
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez832214366
EnsemblENSG00000174804ENSMUSG00000049791
UniProtQ9ULV1Q3V1B2
RefSeq (mRNA)NM_012193NM_008055
RefSeq (protein)NP_036325NP_032081
Location (UCSC)Chr 11:
86.33 - 86.34 Mb
Chr 7:
89.28 - 89.29 Mb
PubMed search[1][2]

Frizzled-4 is a protein that in humans is encoded by the FZD4 gene.[1][2][3] FZD4 has also been designated as CD344 (cluster of differentiation 344).

This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by other experimental evidence.[3]

See also

References

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External links

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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