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...771647 |doi= 10.1002/0470846682.ch14}}</ref>. With sufficient blockage the membrane of the postsynaptic neuron will not depolarize and will thus fail to transm ...[[cardiovascular]] effects – CNS effects usually occur at lower [[blood plasma]] concentrations and additional cardiovascular effects present at higher co

Chloramphenicol is extremely lipid soluble, it remains relatively [[plasma protein binding|unbound to protein]] and is a small molecule: it has a larg ...in liver impairment, and the dose should be adjusted according to measured plasma concentrations. Chloramphenicol is also noted for its cause of "Gray Baby

...''Mycobacterium tuberculosis''. Much of this acid-fast positive bacteria's membrane is [[mycolic acid]] complexed with [[peptidoglycan]], which allows easy mov Orally-administered rifampicin results in peak plasma concentrations in about 2 to 4 hours. [[4-aminosalicyclic acid]] (another a

...ol]] to [[ergosterol]], an essential component of the fungal [[cytoplasmic membrane]], and subsequent accumulation of 14α-methyl sterols.<ref name="DiflucanPI ...a, sputum, and vaginal fluid concentrations are approximately equal to the plasma concentration, following a standard dose range of between 100&nbsp;mg and 4

...fatty meal. Once in the plasma, ribavirin is transported through the cell membrane also by nucleoside transporters.

...by ketamine in cultured neurons causes a hyperpolarizing shift in resting membrane potential and enhances summation of excitatory currents.<ref name="PMID 159 ...s chromatography-mass spectrometry method for determination of ketamine in plasma and its application to human samples. Ther. Drug Monit. 17: 95-100, 1995.</

...ktenli C, Bingol N, Ozdemir IC |title=The effects of metformin and diet on plasma testosterone and leptin levels in obese men |journal=Obes Res |volume=9 |is ...iques also have the benefit of efficiently removing metformin from [[blood plasma]], preventing further lactate over-production.<ref name="cvvh">{{vcite jour

...reached in 6 to 8 hours. It is highly [[plasma protein binding|bound]] to plasma proteins, mostly [[human serum albumin|albumin]]. ...Reimherr FW, Rosenbaum JF, Beasley CM |title=Fluoxetine and norfluoxetine plasma concentrations during relapse-prevention treatment |journal=J Affect Disord

...] in cartilaginous (and hepatic) mitochondria, by diffusing from the inner membrane space as a proton carrier back into the mitochondrial matrix, where it ioni ..., aspirin is absorbed much more slowly during overdose, and [[blood plasma|plasma]] concentrations can continue to rise for up to 24 hours after ingestion.<r

...n the [[sinoatrial node|sinoatrial]] and AV nodes. A less negative resting membrane potential is made, leading to increased excitability. Other, more indirect ...f the [[NaKATPase|Na⁺/K⁺ ATPase]] pump in the [[cell membrane|membranes]] of heart cells (myocytes) and decreases its function. This caus

...actor can be given for correlation of µg/dl against nmol/L. in respect of plasma or serum cortisol estimations, an approximation can be gained by applying a ...f> by decreasing the translocation of [[glucose transporter]]s to the cell membrane,<ref>{{Cite book|last=King|first= Michael W.|title=Lange Q&A USMLE Step 1|e

...lso more sensitive to the effects of benzodiazepines even at similar blood plasma levels. Doses of diazepam are recommended to be about half of those given t ...olarization (biology)|hyperpolarization]] of the post-[[synapse|synaptic]] membrane, owing to the control exerted over negative [[chloride]] [[ion]]s by GABA<s

...agents. A few class II agents, [[propranolol]] for example, also have a [[membrane stabilizing effect]].

...igh again and a cyclical pattern may be established, with most of the drug plasma levels possibly being outside the optimal range. In addition, the drug usua ...ominent approaches is that in which the drug is contained within a polymer membrane or is otherwise encapsulated in a polymer matrix and where the drug diffuse

...the epidermis, between which the two layers interact through the basement membrane zone.<ref name="Rapini" /> Structural components of the dermis are [[colla ...ous conditions#Conditions of the mucous membranes|conditions of the mucous membrane]]), morphology ([[List of cutaneous conditions#Chronic blistering|chronic b

* [[Thyroid hormone plasma membrane transport defect]]

Lymph vessels act as a reservoir from plasma and other substances including cells that leaked from the vascular system a ...s layer functions to mechanically transport fluid and since the [[basement membrane]] on which it rests is discontinuous; it leaks easily.<ref name=pepper>{{ci

...acellular]] region near the [[Cell membrane|plasma membrane]], portions of membrane-associated molecules wait to capture [[phosphate]] and transport it into th ...|doi=10.1074/jbc.M301158200 |pmc=1885458 }}</ref> LPA has been detected in plasma, [[Ascites|ascitic fluid]], [[follicular fluid]], and [[Aqueous humour|aque

...helium-like monolayer of fibroblastic reticular cells anchored to basement membrane-like extracellular matrix|journal= International Immunology|volume=13|issue * The ''medullary cords'' are cords of lymphatic tissue, and include [[plasma cell]]s and [[B cell]]s

*Diffusely distributed lymphoid cells and plasma cells in the [[lamina propria]] of the gut Image:Gray1082.png|Section of mucous membrane of human rectum. X 60.

...gh a variety of protein pumps and calcium exchangers located on the plasma membrane and sarcoplasmic reticulum. This reduction in calcium removes the stimulus

...[[sarcoplasmic reticulum]] via exchangers and expulsion across the plasma membrane.<ref>[http://advan.physiology.org/cgi/content/full/27/4/201 American Physio ...through modulation of [[voltage sensitive calcium channel]]s in the plasma membrane.

...d [[ions]] to diffuse through tight junctions which leave gaps of unjoined membrane which are called intercellular clefts. Tight junctions can be further divid ...ow red and white blood cells (7.5μm - 25μm diameter) and various [[Blood plasma|serum]] proteins to pass, a process that is aided by a discontinuous basal

...author = Olah Z ''et al.'' | year = 2001 | title = Ligand-induced dynamic membrane changes and cell deletion conferred by vanilloid receptor 1 | journal = [[J

...h as synaptotagmin and synaptobrevin interact to fuse the vesicle into the membrane. Phosphorylation also has its own set of proteins involved that work toget ...duced budding of vesicle containing neurotransmitters from the presynaptic membrane. By studying the intracellular mechanisms involved in neural apoptosis aft

'''Amyloid precursor protein''' (APP) is an [[integral membrane protein]] expressed in many [[biological tissue|tissues]] and concentrated ...= | issn = }}</ref> The amyloid beta region of the protein, located in the membrane-spanning domain, is not well conserved across species and has no obvious co

...channels''' are proteins that serve as [[ion channels]] across the plasma membrane of heart and brain cells<ref>Luthi A, McCormick DA. 1998. Neuron. H-current ...s-Prot entry<!-- Bot generated title -->]</ref> Each subunit comprises six membrane-spanning (S1–6) domains which include a putative voltage sensor (S4) and

...Some chemical messengers, such as testosterone, can pass through the cell membrane, and bind directly to receptors in the cytoplasm or nucleus. ...r example of extracellular signaling molecules that may cross the [[plasma membrane]] due to their [[Lipophilicity|lipophilic]] or [[Hydrophobe|hydrophobic]] n

...f selectivity filter, '''5''' - [[phosphorylation]] site, '''6''' - [[cell membrane]].]] ...= | url = | accessdate = }}</ref> They are present in the [[cell membrane|membrane]]s that surround all [[cell (biology)|biological cell]]s. The study of ion

...lfaxalone is metabolised rapidly in the liver. Alfaxalone has a very short plasma elimination half-life in dogs and cats

...[[plasma (physics)|plasma]] using [[electrode]]s. The interaction of this plasma with the electrodes generates ultraviolet [[photon]]s, which then excite th |title=The plasma behind the plasma TV screen