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| class1 = [[Dihydrofolate reductase]] [[enzyme inhibitor|inhibitor]] (16.7%) Trimethoprim acts by interfering with the action of bacterial [[dihydrofolate reductase]], inhibiting synthesis of tetrahydrofolic acid.

...class of [[chemotherapy|chemotherapeutic]] agents known as [[dihydrofolate reductase inhibitor]]s. Trimethoprim was formerly marketed by [[GlaxoSmithKline]] und Trimethoprim acts by interfering with the action of bacterial [[dihydrofolate reductase]], inhibiting synthesis of [[folic acid|tetrahydrofolic acid]]. Tetrahydrof

| group1 = [[Dihydrofolate reductase inhibitor|DHFR inhibitors]]<BR>(antifols)

| group1 = [[Dihydrofolate reductase inhibitor|DR inhibitor]]

| list1 = ''[[dihydrofolate reductase inhibitor]]'' ([[Aminopterin]], [[Methotrexate]], [[Pemetrexed]], [[Pralatr ''[[halogenated]]/[[ribonucleotide reductase inhibitor]]s'' ([[Cladribine]], [[Clofarabine]], [[Fludarabine]])<BR>

...e Derivatives as Potent Inhibitors of Cryptosporidium parvum Dihydrofolate Reductase: Structure-Activity and Structure-Selectivity Correlations" Nelson et al. 2

...]:'' [[IMP dehydrogenase]]{{·}} [[GMP synthase]]{{·}} ''reverse'' ([[GMP reductase]]) ...}} [[DCMP deaminase]]{{·}} [[Thymidylate synthase]]{{·}} [[Dihydrofolate reductase]]