From Self-sufficiency
Jump to: navigation, search
Monoclonal antibody
Type ?
Source Template:Infobox drug/mab source
Target GD2
Clinical data
Routes of
ATC code none
Script error: No such module "TemplatePar".Expression error: Unexpected < operator.

3F8 is a murine IgG3[1] monoclonal antibody which binds to GD2.[2]

It has been used in the detection and treatment of neuroblastoma. For imaging neuroblastoma, it is labelled with one of the radioisotopes iodine-124 and iodine-131.[3][4][5]

See also


Cite error: Invalid <references> tag; parameter "group" is allowed only.

Use <references />, or <references group="..." />

  1. Kushner BH, Cheung NK (1989). "GM-CSF enhances 3F8 monoclonal antibody-dependent cellular cytotoxicity against human melanoma and neuroblastoma". Blood. 73 (7): 1936–41. PMID 2653466. 
  2. "Sloan-Kettering - Neuroblastoma: 3F8 Monoclonal Antibody Therapy Q & A". Retrieved 2008-02-19. 
  3. "ACS :: New Drug Targets Tough
    Childhood Cancer"
    . Retrieved 2008-02-19.
  4. Yeh SD, Larson SM, Burch L; et al. (1991). "Radioimmunodetection of neuroblastoma with iodine-131-3F8: correlation with biopsy, iodine-131-metaiodobenzylguanidine and standard diagnostic modalities". J. Nucl. Med. 32 (5): 769–76. PMID 1902508. 
  5. Dauer LT, St Germain J, Williamson MJ; et al. (2007). "Whole-body clearance kinetics and external dosimetry of 131I-3F8 monoclonal antibody for radioimmunotherapy of neuroblastoma". Health Phys. 92 (1): 33–9. doi:10.1097/01.HP.0000231583.32904.6c. PMID 17164597.