Abafungin

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Abafungin
File:Abafungin.png
Systematic (IUPAC) name
N-[4-[2-(2,4-dimethylphenoxy)phenyl]-1,3-thiazol-2-yl]-1,4,5,6-tetrahydropyrimidin-2-amine
Clinical data
Routes of
administration
topical
Identifiers
CAS Number 129639-79-8
ATC code none
PubChem CID 159326
Chemical data
Formula C21H22N4OS
Molar mass 378.491 g/mol[[Script error: No such module "String".]]
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Abafungin (INN) is a broad-spectrum antifungal agent with a novel mechanism of action for the treatment of dermatomycoses.

Abasol is a topical cream formulation of abafungin by York Pharma.[1]

Mechanism of action

Like imidazole- and triazole-class antifungals, abafungin inhibits the fungal cytochrome P450 enzyme 14α-demethylase. This inhibition prevents the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane.

In addition, abafungin inhibits the enzyme sterol 24-C-methyltransferase, modifying the composition of the fungal membrane.

Abafungin has antibiotic activity against gram-positive bacteria as well as sporicidal activity. [2]

References

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  1. York Pharma: Regulatory Update – Abasol
  2. Ginter-Hanselmayer, Gabriele (March 2009), Arbeitsunterlagen zur 42. wissenschaftlichen Fortbildungsveranstaltung für Apothekerinnen und Apotheker: Infektionskrankheiten, Österreichische Apothekerkammer, p. 103