Abafungin
From Self-sufficiency
File:Abafungin.png | |
Systematic (IUPAC) name | |
---|---|
N-[4-[2-(2,4-dimethylphenoxy)phenyl]-1,3-thiazol-2-yl]-1,4,5,6-tetrahydropyrimidin-2-amine | |
Clinical data | |
Routes of administration | topical |
Identifiers | |
CAS Number | 129639-79-8 |
ATC code | none |
PubChem | CID 159326 |
Chemical data | |
Formula | C21H22N4OS |
Molar mass | 378.491 g/mol[[Script error: No such module "String".]] |
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Abafungin (INN) is a broad-spectrum antifungal agent with a novel mechanism of action for the treatment of dermatomycoses.
Abasol is a topical cream formulation of abafungin by York Pharma.[1]
Mechanism of action
Like imidazole- and triazole-class antifungals, abafungin inhibits the fungal cytochrome P450 enzyme 14α-demethylase. This inhibition prevents the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane.
In addition, abafungin inhibits the enzyme sterol 24-C-methyltransferase, modifying the composition of the fungal membrane.
Abafungin has antibiotic activity against gram-positive bacteria as well as sporicidal activity. [2]
References
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- ↑ York Pharma: Regulatory Update – Abasol
- ↑ Ginter-Hanselmayer, Gabriele (March 2009), Arbeitsunterlagen zur 42. wissenschaftlichen Fortbildungsveranstaltung für Apothekerinnen und Apotheker: Infektionskrankheiten, Österreichische Apothekerkammer, p. 103
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