Amiphenazole

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Amiphenazole
200px
Systematic (IUPAC) name
5-phenyl-1,3-thiazole-2,4-diamine
Identifiers
CAS Number 490-55-1
ATC code none
PubChem CID 10275
Chemical data
Formula C9H9N3S
Molar mass 191.253 g/mol[[Script error: No such module "String".]]
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Amiphenazole (Daptazile) is a respiratory stimulant traditionally used as an antidote for barbiturate or opiate overdose, usually in combination with bemegride,[1][2] as well as poisoning from other sedative drugs[3][4] and treatment of respiratory failure from other causes.[5] It was considered particularly useful as it could counteract the sedation and respiratory depression produced by morphine but with less effect on analgesia.[6][7] It is still rarely used in medicine in some countries, although it has largely been replaced by more effective respiratory stimulants such as doxapram and specific opioid antagonists such as naloxone.[8][9]


References

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Other respiratory system products (R07)
Lung surfactants
Respiratory stimulants
Almitrine • Amiphenazole • Bemegride • Dimefline • Doxapram • Etamivan • Mepixanox • Nikethamide • Pentetrazol • Prethcamide
5-HT4 receptor agonists
Other agents for treating respiratory depression

M: RES

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it:Amifenazolo
  1. ↑ Worlock A. Barbiturate poisoning treated with amiphenazole and bemegride. British Medical Journal. 1956 Nov 10;2(5001):1099-101. PMID 13364395
  2. ↑ Mears GW. Massive doses of bemegride and amiphenazole in treatment of barbiturate poisoning. British Medical Journal. 1958 Mar 29;1(5073):757-8. PMID 13510792
  3. ↑ Dotevall G, Herner B. Treatment of acute primidone poisoning with bemegride and amiphenazole. British Medical Journal. 1957 Aug 24;2(5042):451-2. PMID 13446511
  4. ↑ Rowell NR. Treatment of glutethimide poisoning with bemegride and amiphenazole. Lancet. 1957 Feb 23;272(6965):407-9. PMID 13407028
  5. ↑ Little GM. Use of amiphenazole in respiratory failure. British Medical Journal. 1962 Jan 27;1(5273):223-6. PMID 14465883
  6. ↑ McKeogh J, Shaw FH. Further experience with amiphenazole and morphine in intractable pain. British Medical Journal. 1956 Jan 21;1(4959):142-4. PMID: 13276651
  7. ↑ Gershon S, Bruce DW, Orchard N, Shaw FH. Amiphenazole and morphine in production of analgesia. British Medical Journal. 1958 Aug 9;2(5092):366-8. PMID 13560868
  8. ↑ Gairola RL, Gupta PK, Pandley K. Antagonists of morphine-induced respiratory depression. A study in postoperative patients. Anaesthesia. 1980 Jan;35(1):17-21. PMID 6994518
  9. ↑ O'Neill WM. The cognitive and psychomotor effects of opioid drugs in cancer pain management. Cancer Surveys. 1994;21:67-84. PMID 8565000
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