Antibody-drug conjugate

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Antibody-drug conjugates (ADCs) are a new type of targeted therapy eg for cancer.[1] [2] [3] [4] They consist of an antibody (or antibody fragment such as a single-chain variable fragment (scFv)) linked to a payload drug (often cytotoxic). Hence they are a type of immunoconjugate.

The antibody causes the ADC to bind to the target cancer cells. Often the ADC is then internalised by the cell and the drug is released to do its damage.[5]

Approved:

Examples in clinical trials :[1][6]

Phase III : none as of early 2008

Phase II:

Phase I:

Preclinical:

References

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  1. Jump up to: 1.0 1.1 http://pharmtech.findpharma.com/pharmtech/Ingredients+Insider/Antibody-Drug-Conjugates-A-Marriage-of-Biologics-a/ArticleStandard/Article/detail/522139
  2. Jump up http://pubs.acs.org/doi/abs/10.1021/bc9002019
  3. Jump up http://cancerres.aacrjournals.org/content/66/6/3214.abstract
  4. Jump up http://www.ncbi.nlm.nih.gov/pubmed/17553616
  5. Jump up http://cancerres.aacrjournals.org/content/52/1/127.full.pdf+html Immunoconjugates Containing Novel Maytansinoids: Promising Anticancer Drugs. Chari et al. 1992
  6. Jump up http://pharmtech.findpharma.com/pharmtech/data/articlestandard//pharmtech/232008/522139/i3.jpg ADCs in early 2008
  7. Jump up http://www.cancer.gov/drugdictionary/?CdrID=564399
  8. Jump up http://www.news-medical.net/news/20100827/FDA-denies-accelerated-approval-of-Genentechs-trastuzumab-DM1-%28T-DM1%29-BLA-for-metastatic-breast-cancer.aspx
  9. Jump up http://www.asco.org/ASCOv2/Meetings/Abstracts?&vmview=abst_detail_view&confID=65&abstractID=33509
  10. Jump up http://www.news-medical.net/news/20091206/ImmunoGen-reports-encouraging-clinical-data-of-IMGN901.aspx
  11. Jump up http://www.ncbi.nlm.nih.gov/pubmed/12525512 Cantuzumab mertansine, a maytansinoid immunoconjugate directed to the CanAg antigen: a phase I, pharmacokinetic, and biologic correlative study. 2003 Abstract
  12. Jump up http://jco.ascopubs.org/content/21/2/211.full Cantuzumab Mertansine, a Maytansinoid Immunoconjugate Directed to the CanAg Antigen: A Phase I, Pharmacokinetic, and Biologic Correlative Study. Tolcher et al. 2003. Full text
  13. Jump up http://www.nature.com/leu/journal/vaop/ncurrent/abs/leu2010141a.html