Apixaban
From Self-sufficiency
| File:Apixaban.png | |
| Systematic (IUPAC) name | |
|---|---|
|
1-(4-methoxyphenyl)-7-oxo-6-[4- (2-oxopiperidin-1-yl)phenyl]-4,5- dihydropyrazolo[5,4-c]pyridine- 3-carboxamide | |
| Clinical data | |
| Routes of administration | oral |
| Identifiers | |
| CAS Number | 503612-47-3 |
| ATC code | none |
| PubChem | CID 10182969 |
| ChemSpider | 8358471 |
| Chemical data | |
| Formula | C25H25N5O4 |
| Molar mass | 459.497[[Script error: No such module "String".]] |
| Script error: No such module "collapsible list". | |
Apixaban (manufacturer's designation BMS-562247-01) is a compound being investigated as an anticoagulant. It acts by inhibiting coagulation factor Xa. It is presently undergoing phase III trials in the prevention of venous thromboembolism, together with a number of related competing compounds, such as rivaroxaban.[1] It is being marketed in a joint venture by Pfizer and Bristol-Myers Squibb.[2]
A 2007 trial showed that apixaban was equivalent to enoxaparin/open-label heparin in preventing thrombosis in patients who had undergone a knee replacement.[3]
References
- ↑ Turpie AG (2007). "Oral, direct factor Xa inhibitors in development for the prevention and treatment of thromboembolic diseases". Arterioscler. Thromb. Vasc. Biol. 27 (6): 1238–47. doi:10.1161/ATVBAHA.107.139402. PMID 17379841.
- ↑ "Bristol-Myers Squibb News Release 26 April 2007". Retrieved 2007-09-15.
- ↑ Lassen MR, Davidson BL, Gallus A, Pineo G, Ansell J, Deitchman D (2007). "The efficacy and safety of apixaban, an oral, direct factor Xa inhibitor, as thromboprophylaxis in patients following total knee replacement". J. Thromb. Haemost. 5 (12): 2368–75. doi:10.1111/j.1538-7836.2007.02764.x. PMID 17868430.
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